First Human Imaging Studies with the EXPLORER Total-Body PET Scanner
First Human Imaging Studies with the EXPLORER Total-Body PET Scanner
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DOI：
10.2967/jnumed.119.226498
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发表时间：
2019-03-01
影响因子：
9.3
通讯作者：
Cherry, Simon R.
中科院分区：
文献类型：
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作者：
Badawi, Ramsey D.;Shi, Hongcheng;Cherry, Simon R.
在EXPLORER集团内，世界上第一台全身PET/CT扫描仪的建造最近已经完成。EXPLORER PET/CT扫描仪的194 cm轴向视野首次足以覆盖99%以上人群的整个成人身体，并允许使用帧持续时间短至1 s的全身药代动力学研究。全身覆盖带来的灵敏度大幅增加以及体内任何点检测的立体角增加，使得全身F-18-FDG PET研究能够以前所未有的计数密度进行采集，从而提高所得图像的信噪比。或者，灵敏度增益可用于采集诊断PET图像，其中视场中具有非常少量的活动（25 MBq，0.7 mCi或更少），具有非常短的采集时间（类似于1分钟或更少）或在示踪剂施用后的较晚时间点。我们在这里报告的第一个人类成像研究的EXPLORER扫描仪使用一系列不同的协议，提供初步证据支持这些索赔。这些病例研究为未来仔细对照试验提供了基础，以定量评估全身PET成像可能带来的改善。
Within the EXPLORER Consortium, the construction of the world's first total-body PET/CT scanner has recently been completed. The 194-cm axial field of view of the EXPLORER PET/CT scanner is sufficient to cover, for the first time, the entire human adult body in a single acquisition in more than 99% of the population and allows total-body pharmacokinetic studies with frame durations as short as 1 s. The large increase in sensitivity arising from total-body coverage as well as increased solid angle for detection at any point within the body allows whole-body F-18-FDG PET studies to be acquired with unprecedented count density, improving the signal-to-noise ratio of the resulting images. Alternatively, the sensitivity gain can be used to acquire diagnostic PET images with very small amounts of activity in the field of view (25 MBq, 0.7 mCi or less), with very short acquisition times (similar to 1 min or less) or at later time points after the tracer's administration. We report here on the first human imaging studies on the EXPLORER scanner using a range of different protocols that provide initial evidence in support of these claims. These case studies provide the foundation for future carefully controlled trials to quantitatively evaluate the improvements possible through total-body PET imaging.