TOBACCO AND BLADDER-CANCER IN MALES - INCREASED RISK FOR INHALERS AND SMOKERS OF BLACK TOBACCO
TOBACCO AND BLADDER-CANCER IN MALES - INCREASED RISK FOR INHALERS AND SMOKERS OF BLACK TOBACCO
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DOI：
10.1002/ijc.2910440408
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发表时间：
1989-10-15
影响因子：
6.4
通讯作者：
HEMON, D
中科院分区：
文献类型：
--
作者：
CLAVEL, J;CORDIER, S;HEMON, D
1984年至1987年在法国进行的一项以医院为基础的病例对照研究评估了膀胱癌风险与吸烟之间的关系。分析954例男性患者的吸烟史（477例，对照组477例）。所有吸烟者与非吸烟者膀胱癌的比值比（OR）估计为3.95。风险随吸烟时间和平均每日吸烟量的增加而增加，但这两个参数之间存在显著的相互作用，因为当吸烟时间超过20年时，风险仅随平均每日吸烟量的增加而增加。当单独分析时，发现黑烟消费和吸入都会使风险增加一倍，但它们各自的影响似乎是相互作用的，并且只在吸入器中观察到黑烟吸烟者的风险增加。吸烟黑色和金色烟草的人在戒烟后风险随着时间的推移而变化的方式也有所不同。吸烟黑烟的人在戒烟后的OR比吸烟黄烟的人下降得更快，但戒烟15年后，前者的剩余风险高于后者。
Relationships between risk of bladder cancer and tobacco smoking were assessed from a hospital-based case-control study conducted in France from 1984 to 1987. Smoking history was analyzed for 954 male patients (477 cases and 477 controls). The odds ratio (OR) of bladder cancer was estimated at 3.95 for all smokers vs. non-smokers. The risk increased with duration of smoking and with average daily cigarette consumption, but there was a significant interaction between these 2 parameters, since the risk only increased with average daily consumption when the duration exceeded 20 years. Black tobacco consumption and inhaling were both found to double the risk when analyzed separately, but their respective effects appeared to interact, and an elevated risk for smokers of black tobacco was only observed among inhalers. Smokers of black and blond tobacco also differed in the way in which the risk evolved with time after cessation of smoking. The OR decreased faster after cessation of smoking among smokers of black tobacco than among smokers of blond tobacco, but the residual risk was higher 15 years after cessation among the former than among the latter.