Effect of Mustard Gas Exposure on Incidence of Lung Cancer: A Longitudinal Study
Effect of Mustard Gas Exposure on Incidence of Lung Cancer: A Longitudinal Study
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DOI：
10.1093/aje/kwq426
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发表时间：
2011-03-15
影响因子：
5
通讯作者：
Kohno, Nobuoki
中科院分区：
文献类型：
--
作者：
Doi, Mihoko;Hattori, Noboru;Kohno, Nobuoki
芥子气是一种用于化学战的试剂，是一种具有致癌潜力的烷基化物质。然而，芥子气的确切长期致癌作用尚不清楚。自1952年以来，作者对1929年至1945年在日本广岛奥野岛一家有毒气体工厂工作的前工人进行了健康调查。这项前瞻性研究从1952年至2005年进行，以检查肺癌的发病率在工人谁暴露于芥子气（n = 480），路易氏剂（n = 55），和/或二苯基氰胂（n = 178），以及发病率在未暴露的工人（n = 969）。本文在多阶段致癌的基础上，利用一个转换了年龄尺度的加速危险模型，探讨了暴露与肺癌之间的随机关系。芥子气暴露被发现改变了患肺癌的年龄尺度。首次暴露时年龄<18岁的受试者暴露1年，年龄范围分别下降4.9岁和3.3岁。根据对有毒气体工厂前工人的长期随访，作者得出结论，硫芥降低了人们患肺癌的年龄，而且这种影响随着年龄的增长而下降。
Sulfur mustard, an agent used in chemical warfare, is an alkylating substance with carcinogenic potential. However, the precise long-term carcinogenic effects of mustard gas are unclear. Since 1952, the authors have conducted health surveys of former workers who were employed from 1929 to 1945 in a poisonous gas factory in Okuno-jima, Hiroshima, Japan. This prospective study was undertaken from 1952 to 2005 to examine the incidence of lung cancer among the workers who were exposed to mustard gas (n = 480), lewisite (n = 55), and/or diphenylcyanarsine (n = 178), as well as the incidence among unexposed workers (n = 969). The stochastic relation between exposure and lung cancer was explored on the basis of multistage carcinogenesis by using an accelerated hazard model with a transformed age scale. Mustard gas exposure was found to transform the age scale for developing lung cancer. One year of exposure in subjects 18 years old at first exposure shifted the age scale down by 4.9 years and 3.3 years, respectively. On the basis of the long-term follow-up of former workers in the poisonous gas factory, the authors concluded that sulfur mustard decreased the age at which people were at risk of developing lung cancer and that the effect declined with aging.