Polyunsaturated fatty acid status and aggression in cocaine addicts
Polyunsaturated fatty acid status and aggression in cocaine addicts
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DOI：
10.1016/s0376-8716(03)00168-6
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发表时间：
2003-09-10
影响因子：
4.2
通讯作者：
Hibbeln, JR
中科院分区：
文献类型：
--
作者：
Buydens-Branchey, L;Branchey, M;Hibbeln, JR
背景：越来越多的证据表明，某些低水平的多不饱和脂肪酸 (PUFA) 在侵袭性疾病的病理生理学中发挥作用。 PUFA状态受到营养因素的影响，并且由于我们观察到一些药物滥用者有不良的饮食习惯，我们探讨了有和没有攻击倾向的可卡因成瘾者的脂肪酸（FA）谱可能不同的可能性。我们还探讨了他们在提供标准饮食的住院病房住院两周后 FA 水平发生变化的可能性。方法：测量了药物滥用病房收治的 24 名可卡因成瘾者的血浆 FA 水平。 6 名患者有攻击行为史，18 名则没有。结果：入院后 3.7+/-2.0 天对攻击性和非攻击性患者的 FA 水平进行比较，未发现饱和 FA (SFA) 或单不饱和 FA (MFA) 存在任何显着差异。攻击性患者的 n-6 PUFA 二十二碳五烯酸 (E)PA)、总 n-3 PUFA 和 n-3 PUFA 二十二碳六烯酸 (DHA) 水平显着降低，并且 n-6 与 n-3 PUFA 的比率略有显着增加。入院后 18.4+/-1.3 天进行的测量显示，两个患者组中的大多数 FA 均有所增加。一些 PUFA，尤其是 n-3 系列的 PUFA，在攻击性患者中增加得更为急剧。结果，入院后不久出现的各组之间的 PUFA 差异变得不显着。结论：这些数据表明患者住院前的饮食不是最佳的，并且攻击性个体的饮食可能特别缺乏富含 n-3 的营养素。这些数据还为表明 n-3 缺乏与人类攻击性之间可能存在联系的证据提供了额外的支持。由爱思唯尔科学爱尔兰有限公司出版
Background: There is mounting evidence that low levels of some polyunsaturated fatty acids (PUFAs) play a role in the pathophysiology of aggressive disorders. PUFA status is influenced by nutritional factors and because of our observation that some substance abusers have poor dietary habits, we explored the possibility that the fatty acids (FA) profiles of cocaine addicts with and without aggressive tendencies would differ. We also explored the possibility that their FA levels would change after a 2 week stay on an inpatient unit where a standard diet would be provided. Methods: Plasma levels of FAs were measured in 24 cocaine addicts admitted to an inpatient substance abuse unit. Six patients had a past history of aggression and 18 did not. Results: A comparison of the FA levels of aggressive and non-aggressive patients performed 3.7+/-2.0 days after their admission did not reveal any significant difference in saturated FAs (SFAs) or monounsaturated FAs (MFAs). Aggressive patients had significantly lower levels of the n-6 PUFA docosapentaenoic acid (E)PA), of total n-3 PUFAs and of the n-3 PUFA docosahexaenoic acid (DHA), and a marginally significant increase in the ratio of n-6 to n-3 PUFAs. Measurements performed 18.4+/-1.3 days after admission showed that most FAs had increased in the two patient groups. Some PUFAs, especially those of the n-3 series, increased more sharply in the aggressive patients. As a result, PUFA differences between groups that were present shortly after admission became non-significant. Conclusions: These data suggest that patients' diets prior to their hospitalization were less than optimal and that the diet of the aggressive individuals might have been particularly deficient in n-3 rich nutrients. These data also give additional support to evidence indicating a possible link between an n-3 deficiency and aggression in humans. Published by Elsevier Science Ireland Ltd.