Migration and Tissue Tropism of Innate Lymphoid Cells.
Migration and Tissue Tropism of Innate Lymphoid Cells.
复制标题
先天性淋巴样细胞的迁移和组织向向向向向向向向向向向往。
DOI：
10.1016/j.it.2015.11.003
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发表时间：
2016-01
影响因子：
16.8
通讯作者：
Kim M
中科院分区：
文献类型：
--
作者：
Kim CH;Hashimoto-Hill S;Kim M
先天性淋巴样细胞(ILCs)亚群在各种屏障和非屏障组织中有不同的分布，在组织内稳态和对病原体攻击的组织特异性反应中发挥重要作用。最近的发现为引导ILC向周围组织迁移的分子机制提供了洞察力，揭示了不同ILC亚群之间的共同特征以及重要的区别。最近的研究也强调了组织特异性信号对ILC迁移的影响，以及局部免疫环境的重要性。我们在这里回顾了这些发现，并讨论了不同ILC亚群的迁移模式和组织趋向性如何与这些细胞的发育和分化有关，以及与ILC介导的天然和获得性免疫反应的组织特异性调节有关。在此背景下，我们概述了有待解决的问题和未来研究的重要领域。
Innate lymphoid cell (ILCs) subsets differentially populate various barrier and non-barrier tissues, where they play important roles in tissue homeostasis and tissue-specific responses to pathogen attack. Recent findings have provided insight into the molecular mechanisms that guide ILC migration into peripheral tissues, revealing common features among different ILC subsets as well as important distinctions. Recent studies have also highlighted the impact of tissue-specific cues on ILC migration, and the importance of the local immunological milieu. We review these findings here and discuss how the migratory patterns and tissue tropism of different ILC subsets relate to the development and differentiation of these cells, and to ILC-mediated tissue-specific regulation of innate and adaptive immune responses. In this context we outline open questions and important areas of future research.