TISSUE-PLASMINOGEN ACTIVATOR INDUCTION IN PURKINJE NEURONS AFTER CEREBELLAR MOTOR LEARNING
TISSUE-PLASMINOGEN ACTIVATOR INDUCTION IN PURKINJE NEURONS AFTER CEREBELLAR MOTOR LEARNING
复制标题
DOI：
10.1126/science.270.5244.1992
复制
发表时间：
1995-12-22
期刊：
影响因子：
56.9
通讯作者：
BICKFORD, PC
中科院分区：
文献类型：
--
作者：
SEEDS, NW;WILLIAMS, BL;BICKFORD, PC
小脑皮质与复杂运动技能的学习有关。这种学习可能需要浦肯野细胞输入的突触重构。组织纤溶酶原激活物(TPA)是一种细胞外丝氨酸蛋白酶，参与了多种非神经组织的重建，并与神经元的发育和再生有关。原位杂交显示，在接受复杂运动任务训练的大鼠浦肯野神经元中，tPA信使RNA的表达在一小时内增加。抗tPA抗体也显示了与小脑浦肯野细胞相关的tPA蛋白的诱导。因此，tPA在运动学习过程中的诱导可能在活性依赖的突触可塑性中发挥作用。
The cerebellar cortex is implicated in the learning of complex motor skills. This learning may require synaptic remodeling of Purkinje cell inputs. An extracellular serine protease, tissue plasminogen activator (tPA), is involved in remodeling various nonneural tissues and is associated with developing and regenerating neurons. in situ hybridization showed that expression of tPA messenger RNA was increased in the Purkinje neurons of rats within an hour of their being trained for a complex motor task. Antibody to tPA also showed the induction of tPA protein associated with cerebellar Purkinje cells. Thus, the induction of tPA during motor learning may play a role in activity-dependent synaptic plasticity.