PREOPTIC-ANTERIOR HYPOTHALAMIC NEURONS - THERMOSENSITIVITY IN RAPID EYE-MOVEMENT SLEEP
PREOPTIC-ANTERIOR HYPOTHALAMIC NEURONS - THERMOSENSITIVITY IN RAPID EYE-MOVEMENT SLEEP
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DOI：
10.1152/ajpregu.1995.269.5.r1250
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发表时间：
1995-11-01
影响因子：
2.8
通讯作者：
SZYMUSIAK, R
中科院分区：
文献类型：
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作者：
ALAM, MN;MCGINTY, D;SZYMUSIAK, R
采用局部加热和冷却的方法，对自由运动猫在清醒、非快速眼动（NREM）睡眠和快速眼动（REM）睡眠时，下丘脑内侧前叶/前叶（POAH）的15个温敏神经元（WSNs）和19个冷敏神经元（CSNs）的热敏性进行了测试。热敏性是量化的三个标准，Q(10)，脉冲每秒每摄氏度，和百分比变化每摄氏度。无论使用何种标准，与清醒和非快速眼动睡眠相比，WSNs在快速眼动睡眠期间的热敏性没有显着变化。相比之下，csn在REM睡眠期间的平均热敏性比清醒时降低。csn作为一个群体在快速眼动睡眠中不保持显著的热敏性。这些发现与有证据表明，在快速眼动睡眠中，对降温的热效应反应会消失，而对变暖的一些反应会保留下来，这是一致的。
The thermosensitivity of 15 warm-sensitive neurons (WSNs) and 19 cold-sensitive neurons (CSNs) from the medial preoptic/anterior hypothalamus (POAH) was tested during wakefulness, non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep by local POAH warming and cooling in freely moving cats. Thermosensitivity was quantified by three criteria, Q(10), impulses per second per degree Celsius, and percent change per degree Celsius. Irrespective of the criterion used, WSNs did not exhibit a significant change in thermosensitivity during REM sleep compared with wakefulness and NREM sleep. In contrast, CSNs exhibited decreased mean thermosensitivity during REM sleep compared with wakefulness. CSNs as a group did not retain significant thermosensitivity in REM sleep. These findings are consistent with evidence that thermoeffector responses to cooling are lost in REM sleep, whereas some responses to warming are preserved.