A MORPHOLOGIC AND MORPHOMETRIC ANALYSIS OF FETAL LUNG DEVELOPMENT IN THE SHEEP
A MORPHOLOGIC AND MORPHOMETRIC ANALYSIS OF FETAL LUNG DEVELOPMENT IN THE SHEEP
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DOI：
10.1002/ar.1092010410
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
ROBINSON, PM
中科院分区：
文献类型：
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作者：
ALCORN, DG;ADAMSON, TM;ROBINSON, PM
与体型较小的实验动物相比，绵羊的胎肺发育进入了较晚的成熟阶段。用组织学、形态计量学和超微结构技术描述了该种可识别的4个肺发育阶段：胚胎期、假腺期、小管期和肺泡期。在假腺体阶段，主要呼吸道以离心性方式发育。软骨、腺体、肌肉、血管和神经成分从小就存在于主要的气道壁中。在小管期，肺的体积扩张是通过大终末间隙的快速生长完成的。在末期，大的终末间隙被肺泡峰分割形成肺泡。肺泡衬里上皮在后两个阶段分化，肺泡表面积显著增加，尤其是在肺泡期；肺毛细血管表面积也伴随着肺泡发育。因此，就在出生前，胎羊肺有一个发达的呼吸道系统和肺泡网络，为出生后的气体交换做准备。
In the sheep, fetal lung development proceeds to a later stage of maturity than in smaller laboratory animals. Of the 4 stages in pulmonary development recognizable in this species, embryologic, pseudoglandular, canalicular and aveolar, the latter 3 are described using histologic, morphometric and ultrastructural techniques. During the pseudoglandular stage, the major airways developed centrifugally. Cartilaginous, glandular, muscular, vascular and neural elements were present in major airway walls from an early age. During the canalicular stage volume expansion of the lung was accomplished by rapid growth of large terminal spaces. In the final stage alveoli were formed following subdivision of the large terminal spaces by alveolar crests. The alveolar lining epithelium differentiated during the latter 2 stages producing a large increase in alveolar surface area, particularly during the alveolar stage; a large increase in pulmonary capillary surface area also accompanied alveolar development. Thus, just prior to birth, the fetal sheep lung has a well-developed airway system and alveolar network, in preparation for postnatal gas exchange.