Experimental Study on the Postmortem Redistribution of the Substituted Phenethylamine, 25B-NBOMe
Experimental Study on the Postmortem Redistribution of the Substituted Phenethylamine, 25B-NBOMe
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取代苯乙胺 25B-NBOMe 死后再分布的实验研究
DOI：
10.1111/1556-4029.13583
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发表时间：
2017
影响因子：
1.6
通讯作者：
Ikegaya Hiroshi
中科院分区：
文献类型：
--
作者：
Shintani-Ishida Kaori;Saka Kanju;Nakamura Mami;Yoshida Ken-ichi;Ikegaya Hiroshi
2-（4-溴-2，5-二甲氧基苯基）-N-（2-甲氧基苄基）乙胺（25 B-NBOMe）是一种取代的苯乙胺，自2014年以来在全球范围内非常流行。最近，在涉及致命的25 B-NBOMe中毒的尸检病例中，我们发现死亡后约2天心脏血液中25 B-NBOMe浓度的死后增加。本研究的目的是研究25 B-NBOMe的分布，并使用大鼠模型再现死后再分布。在腹膜内注射25 B-NBOMe（0.5 mg/kg）后30 min处死Sprague-道利大鼠，并放置0、3、6、9、15或24 h（每个时间点6只大鼠）。死后6小时，心脏血液中的死后25 B-NBOMe浓度增加了10倍以上。25 B-NBOMe主要在肺中积累。此外，这种死后再分布甚至发生在25 B-NBOMe给药后1周死亡的大鼠中。这些结果表明，在25 B-NBOMe的毒理学分析中应注意样品收集和数据解释。
2‐(4‐Bromo‐2,5‐dimethoxyphenyl)‐N‐(2‐methoxybenzyl)ethanamine (25B‐NBOMe) is a substituted phenethylamine, which has become highly prevalent worldwide since 2014. Recently, in an autopsy case involving fatal 25B‐NBOMe intoxication, we found the postmortem increase of 25B‐NBOMe concentration in the cardiac blood approximately 2 days after death. The aim of this study was to investigate the distribution of 25B‐NBOMe and reproduce the postmortem redistribution using a rat model. Sprague‐Dawley rats were killed 30 min after intraperitoneal injection of 25B‐NBOMe (0.5 mg/kg) and left for 0, 3, 6, 9, 15, or 24 h (six rats at each time point). Postmortem 25B‐NBOMe concentrations in the cardiac blood increased by more than 10‐fold at 6‐h postmortem. 25B‐NBOMe accumulated primarily in the lung. Moreover, this postmortem redistribution occurred even in rats that had died 1 week following the 25B‐NBOMe administration. These findings indicate that attention should be paid to sample collection and data interpretation in the toxicological analysis of 25B‐NBOMe.