secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids.
secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids.
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DOI：
10.1080/19336934.2017.1291104
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发表时间：
2017-07-03
期刊：
影响因子：
1.2
通讯作者：
Rincon-Limas DE
中科院分区：
文献类型：
--
作者：
De Mena L;Chhangani D;Fernandez-Funez P;Rincon-Limas DE
Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders. These aggregates are deposited inside or outside the cell due to hereditary mutations, environmental exposures or even normal aging. Cumulative evidence indicates that the heat shock chaperone Hsp70 possesses robust neuroprotection against various intracellular amyloids in Drosophila and mouse models. However, its protective role against extracellular amyloids was largely unknown as its presence outside the cells is very limited. Our recent manuscript in PNAS revealed that an engineered form of secreted Hsp70 (secHsp70) is highly protective against toxicity induced by extracellular deposition of the amyloid-β42 (Aβ42) peptide. In this Extra View article, we extend our analysis to other members of the heat shock protein family. We created PhiC31-based transgenic lines for human Hsp27, Hsp40, Hsp60 and Hsp70 and compared their activities in parallel against extracellular Aβ42. Strikingly, only secreted Hsp70 exhibits robust protection against Aβ42-triggered toxicity in the extracellular milieu. These observations indicate that the ability of secHsp70 to suppress Aβ42 insults is quite unique and suggest that targeted secretion of Hsp70 may represent a new therapeutic approach against Aβ42 and other extracellular amyloids. The potential applications of this engineered chaperone are discussed.
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影响因子：
16.2
作者：
Wen X;Tan W;Westergard T;Krishnamurthy K;Markandaiah SS;Shi Y;Lin S;Shneider NA;Monaghan J;Pandey UB;Pasinelli P;Ichida JK;Trotti D
通讯作者：
Trotti D
影响因子：
3.7
作者：
Schultz SW;Nilsson KP;Westermark GT
通讯作者：
Westermark GT
影响因子：
5.3
作者：
Magrané, J;Smith, RC;Querfurth, HW
通讯作者：
Querfurth, HW
DOI：
10.1096/fj.11-185983
发表时间：
2012-01
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Kumita JR;Helmfors L;Williams J;Luheshi LM;Menzer L;Dumoulin M;Lomas DA;Crowther DC;Dobson CM;Brorsson AC
通讯作者：
Brorsson AC
影响因子：
3.5
作者：
Casas-Tinto, Sergio;Zhang, Yan;Fernandez-Funez, Pedro
通讯作者：
Fernandez-Funez, Pedro