Characteristics and comorbidity of ADHD sib pairs in the Central Valley of Costa Rica.
Characteristics and comorbidity of ADHD sib pairs in the Central Valley of Costa Rica.
复制标题
哥斯达黎加中央山谷 ADHD 同胞对的特征和合并症。
DOI：
10.1016/j.comppsych.2011.05.003
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发表时间：
2012
影响因子：
7.3
通讯作者：
Mathews,CarolA
中科院分区：
文献类型：
--
作者：
Schuler,Jovita;Weiss,NicholasT;Chavira,DeniseA;McGough,JamesJ;Berrocal,Monica;Sheppard,Brooke;Vaglio,Evelyn;Fournier,Eduardo;Herrera,LuisDiego;Mathews,CarolA
遗传流行病学研究表明，注意力缺陷/多动障碍（ADHD）的遗传易感性在很大程度上是存在的，但也表明遗传学是复杂的，在不同的人群或种族群体之间可能存在差异。第四版（DSM-IV）定义的ADHD亚型和共病条件计算样本的157 ADHD影响的儿童（先证者和兄弟姐妹）招募的遗传研究使用标准化的方法。先证者中ADHD亚型以混合型为主（69.5%），其次为注意力不集中（27.4%）和多动冲动型（3.2%）。焦虑障碍占55.9%，破坏性行为障碍占30.9%，抽动秽语障碍占17.0%。先证者和兄弟姐妹表现出较高的sib-sib一致性焦虑disorders.CONCLUSIONSADHD在哥斯达黎加的临床和人口统计学特征相似，ADHD在世界其他地区看到，虽然并发精神疾病的发病率有所不同，从那些以前报道的拉丁美洲样本。共病焦虑症是普遍存在的，具有较高的同胞-同胞一致率，并可能代表一个独特的，同质的亚组适合遗传研究。
BACKGROUNDWhile genetic epidemiological studies demonstrate a substantial degree of genetic predisposition for attention-deficit/hyperactivity disorder (ADHD), they also suggest that the genetics are complex and may differ between populations or ethnic groups.OBJECTIVEThis study describes the phenomenology of siblings with ADHD from the genetically isolated population of the Central Valley of Costa Rica.METHODSRates of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)–defined ADHD subtypes and comorbid conditions were calculated in a sample of 157 ADHD-affected children (probands and siblings) recruited for genetic studies using standardized approaches. Sib-sib comparisons and logistic regressions were conducted to identify significant patterns of concordance.RESULTSCombined-type ADHD (69.5%) was the most common subtype among probands, followed by the inattentive (27.4%), and hyperactive-impulsive (3.2%) subtypes. Anxiety disorders were prevalent (55.9%), as were disruptive behavior disorders (30.9%) and Tourette disorder (17.0%). Probands and siblings showed high sib-sib concordance for anxiety disorders.CONCLUSIONSADHD in Costa Rica is similar in clinical and demographic characteristics to ADHD seen in other parts of the world, although the rates of co-occurring psychiatric disorders differ somewhat from those previously reported in Latin American samples. Comorbid anxiety is prevalent, with high rates of sib-sib concordance, and may represent a distinct, homogeneous subgroup suitable for genetic studies.