Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women.
Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women.
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体重指数对中年男性和绝经后女性载脂蛋白 A-I 动力学的影响。
DOI：
10.1016/j.metabol.2007.01.022
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Marsh,JulianB
中科院分区：
文献类型：
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作者：
Welty,FrancineK;Lichtenstein,AliceH;Lamon-Fava,Stefania;Schaefer,ErnstJ;Marsh,JulianB
按性别检查体重指数 (BMI) 和肥胖对载脂蛋白 (apo) A-I 水平和动力学的影响。 19 名男性和 13 名绝经后女性在进食状态下持续注射氘化亮氨酸，测定了 Apo A-I 动力学。与非肥胖男性相比，非肥胖女性的高密度脂蛋白胆固醇 (HDL-C) 和载脂蛋白 A-I 水平较高，因为载脂蛋白 A-I 生成率 (PR) 高出 48% (P = .05)。肥胖对女性的 apo A-I 动力学没有显着影响。相比之下，与非肥胖男性相比，肥胖男性的 apo A-I 水平降低了 9%，因为分解代谢率 (FCR) 高出 64%，但部分分解代谢率 (FCR) 高出 47%，这部分抵消了肥胖男性的载脂蛋白 A-I 水平。肥胖女性的 HDL-C 比肥胖男性高 52%（分别为 50 与 33 mg/dL；P = .012），这一发现与肥胖男性更快的 apo A-I FCR 有关。在男性中，BMI 与 apo A-I FCR (r = 0.84，P < .001) 和 PR (r = 0.79，P < .001) 直接相关，但在女性中则不然。在男性中，62% 的 PR 变异性和 71% 的 FCR 变异性是由 BMI 造成的，而在女性中，这一比例分别只有 3% 和 23%。总之，BMI 对男性的 apo A-I PR 和 FCR 有显着影响，但对女性则没有影响。
The effect of body mass index (BMI) and obesity on apolipoprotein (apo) A-I levels and kinetics was examined by gender. Apo A-I kinetics were determined with a primed, constant infusion of deuterated leucine in the fed state in 19 men and 13 postmenopausal women. Compared with nonobese men, nonobese women had a higher level of high-density lipoprotein cholesterol (HDL-C) and apo A-I due to a 48% higher apo A-I production rate (PR) (P = .05). Obesity had no significant effects on apo A-I kinetics in women. In contrast, compared with nonobese men, obese men had a 9% lower apo A-I level due to a 64% higher fractional catabolic rate (FCR) partially offset by a 47% higher PR. Obese women had a 52% higher HDL-C than obese men (50 vs 33 mg/dL, respectively; P = .012), a finding related to the faster apo A-I FCR in obese men. BMI was directly correlated with apo A-I FCR (r = 0.84, P < .001) and PR (r = 0.79, P < .001) in men but not in women. Sixty-two percent of the variability in PR and 71% of the variability in FCR were due to BMI in men and only 3% and 23%, respectively, in women. In conclusion, BMI has a significant effect on apo A-I PR and FCR in men but not in women.