Exercise decreases speedball self-administration
Exercise decreases speedball self-administration
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DOI：
10.1016/j.lfs.2014.08.005
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发表时间：
2014-10-02
期刊：
影响因子：
6.1
通讯作者：
Smith, Mark A.
中科院分区：
文献类型：
--
作者：
Lacy, Ryan T.;Strickland, Justin C.;Smith, Mark A.
目的：流行病学研究报告说，运动的人不太可能滥用药物。临床前研究报告称，跑步机或轮跑形式的运动可靠地减少了精神兴奋剂和阿片类药物的自我管理。迄今为止，临床前研究仅检查了运动对单个药物维持的反应的影响，而不是多种药物的组合。这限制了这些研究的翻译吸引力，因为多种药物滥用在药物滥用人群中很常见。本研究的目的是检查运动的影响，对自我管理的速度球，可卡因和海洛因的组合，经常遇到的静脉注射吸毒population.Main方法：雌性大鼠断奶时获得，并分配到久坐不动或行使条件。将不活动的大鼠饲养在标准笼中，不允许超出正常笼的范围进行运动;将运动的大鼠饲养在具有活动轮的类似笼中。6周后，向大鼠植入静脉内导管并训练其自我施用可卡因、海洛因以及可卡因和海洛因的剂量组合（即，主要发现：与单独使用相应剂量的可卡因和海洛因相比，速度球剂量维持了更高的反应水平。重要的是，响应维持可卡因，海洛因，和speedball是较低的运动大鼠比久坐rates.Significance：这些数据表明，运动减少了自我管理的speedball，并表明，运动可能会减少滥用药物的组合，传统上一直抵抗治疗。(C)版权所有© 2014 Elsevier Inc.
Aims: Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids. To date, preclinical studies have only examined the effects of exercise on responding maintained by individual drugs and not by combinations of multiple drugs. This limits the translational appeal of these studies because polydrug abuse is common among substance abusing populations. The purpose of this study was to examine the effects of exercise on the self-administration of speedball, a combination of cocaine and heroin that is frequently encountered in intravenous drug abusing populations.Main methods: Female rats were obtained at weaning and assigned to sedentary or exercising conditions. Sedentary rats were housed in standard cages that permitted no exercise beyond normal cage ambulation; exercising rats were housed in similar cages with an activity wheel. After 6 weeks, rats were implanted with intravenous catheters and trained to self-administer cocaine, heroin, and dose combinations of cocaine and heroin (i.e., speedball) on a progressive ratio schedule of reinforcement.Key findings: Doses of speedball maintained greater levels of responding than corresponding doses of cocaine and heroin alone. Importantly, responding maintained by cocaine, heroin, and speedball was lower in exercising rats than sedentary rats.Significance: These data indicate that exercise decreases the self-administration of speedball and suggest that exercise may reduce the abuse of drug combinations that have traditionally been resistant to treatment. (C) 2014 Elsevier Inc All rights reserved.