Alveolar epithelial stem and progenitor cells: emerging evidence for their role in lung regeneration.
Alveolar epithelial stem and progenitor cells: emerging evidence for their role in lung regeneration.
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DOI：
10.2174/092986712804485872
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发表时间：
2012-11
影响因子：
4.1
通讯作者：
A. Hoffman;E. Ingenito
中科院分区：
文献类型：
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作者：
A. Hoffman;E. Ingenito
影响肺泡的肺损伤，例如肺气肿、肺纤维化和急性肺损伤，是昂贵且普遍的问题。此外，肺泡损伤和气体交换受损的程度与预后和生存率密切相关。因此，肺泡隔室的修复和再生机制受到越来越多的关注，作为新的方法来研究干细胞和祖细胞在这一地区展开。II型肺泡上皮细胞作为肺损伤后I型（AECI）和II型（AECII）肺泡上皮细胞的唯一来源的作用最近受到了挑战;最近，研究人员描述了干祖细胞，其功能类似于AECII的前体，无论是在体外还是在体内，在小鼠和人类中。探索自我更新和多能性的技术已经被严格应用于这些假定的干祖细胞群体，迄今为止的数据是令人信服的。本文综述了肺泡再生研究的背景，旨在为最近发现的可能有助于这一过程的干祖细胞提供背景。
Lung injuries that impact the alveolus, such as emphysema, pulmonary fibrosis, and acute lung injury, are costly and prevalent problems. Moreover, the extent of alveolar injury and impairment of gas exchange is strongly associated with prognosis and survival. Thus, mechanisms of repair and regeneration of the lung alveolar compartment have received mounting attention as newer approaches to the study of stem and progenitor cells in this region unfold. The role of type II alveolar epithelial as the sole source of type I (AECI) and II (AECII) alveolar epithelial cells following lung injury has been recently challenged; recently, investigators have described stemprogenitor cells that function like precursors to AECII either in vitro or in vivo, both in mice and humans. Techniques to explore selfrenewal and multipotency have been rigorously applied to these putative stem-progenitor cell populations and the data thus far is compelling. This review provides background to the study of alveolar regeneration with the aim to provide context to the recent discoveries of putative stem-progenitor cells that may contribute to this process.