Influence of high-fat diet on gut microbiota: a driving force for chronic disease risk.
Influence of high-fat diet on gut microbiota: a driving force for chronic disease risk.
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DOI：
10.1097/mco.0000000000000209
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发表时间：
2015-09
影响因子：
3.1
通讯作者：
Herbert KM
中科院分区：
文献类型：
--
作者：
Murphy EA;Velazquez KT;Herbert KM
这篇综述将回顾关于高脂饮食(HFD)诱导的肠道微生物区系改变以及随后的肥胖和慢性病风险发展的最新科学文献。HFDs的过度消费无疑是肥胖症流行的原因之一。然而，造成这种关系的机制可能比简单的能量平衡概念复杂得多。事实上，新出现的文献已经将HFD诱导的肠道微生物区系改变与肥胖流行联系在一起。HFD的消费通常会导致类杆菌减少，Firmicum增加，这些变化与肥胖和随后的慢性病发展有关。这种作用的潜在机制包括1)改善能量收集和储存的能力，2)增强肠道通透性和炎症。我们重点介绍了将HFD诱导的生物失调与肥胖联系起来的最重要的最新进展，探索了这种效应的可能机制，研究了对疾病发展的影响，并评估了以肠道微生物群为治疗靶点以减少肥胖的可能性。更好地了解HFD与肠道微生物区系改变之间的联系机制对于调节失调和随后促进抗肥胖效果是必要的。
This review will examine the recent scientific literature surrounding high-fat-diet (HFD)-induced alterations in gut microbiota and subsequent development of obesity and chronic disease risk. Excessive consumption of HFDs has undoubtedly contributed to the obesity epidemic. However, the mechanisms responsible for this relationship are likely to be more complex than the simple concept of energy balance. In fact, emerging literature has implicated HFD-induced alterations in gut microbiota in the obesity epidemic. HFD consumption generally leads to a decrease in Bacteroidetes and an increase in Firmicutes, alterations that have been associated with obesity and subsequent development of chronic diseases. Potential mechanisms for this effect include 1) an improved capacity for energy harvest and storage and, 2) enhanced gut permeability and inflammation. We highlight the most important recent advances linking HFD-induced dysbiosis to obesity, explore the possible mechanisms for this effect, examine the implications for disease development, and evaluate the possibility of therapeutic targeting of the gut microbiome to reduce obesity. A better understanding of the mechanisms linking HFD to alterations in gut microbiota is necessary to allow for the regulation of dysbiosis and ensuing promotion of anti-obesity effects.