Preoperative hypoalbuminemia is associated with an increased risk for intra-abdominal septic complications after primary anastomosis for Crohn's disease.
Preoperative hypoalbuminemia is associated with an increased risk for intra-abdominal septic complications after primary anastomosis for Crohn's disease.
复制标题
术前低白蛋白血症与克罗恩病初次吻合术后腹内脓毒症并发症的风险增加相关
DOI：
10.1093/gastro/gox002
复制
发表时间：
2017-11
影响因子：
3.6
通讯作者：
Lan P
中科院分区：
文献类型：
--
作者：
Liu X;Wu X;Zhou C;Hu T;Ke J;Chen Y;He X;Zheng X;He X;Hu J;Zhi M;Gao X;Hu P;Wu X;Lan P
本研究旨在评估术前低白蛋白血症对克罗恩病（CD）患者一期吻合术后腹腔内感染性并发症（IASCs）发生的影响。
研究纳入了2007年至2015年期间所有接受肠切除一期吻合术的CD患者。采用单因素和多因素分析评估术前低白蛋白血症（<30 g/L）与IASCs风险的相关性。
共纳入124例符合条件的患者，其中117例（94.4%）有术前白蛋白水平数据。13例（11.7%）患者存在术前低白蛋白血症。术前低白蛋白血症患者从确诊到手术的时间比无此情况的患者更长（p = 0.012）。术前低白蛋白血症患者更有可能有术前使用5 - 氨基水杨酸的病史（p = 0.013），且术中更易发现小肠梗阻（p = 0.015）。在所有患者中，24例（19.4%）发生了术后IASCs。单因素分析显示，术前低白蛋白血症患者发生IASCs的风险增加（p = 0.012）。多因素分析证实了术前低白蛋白血症与IASCs之间的关联（优势比4.67，95%置信区间：1.28 - 17.04，p = 0.02）。当将术前白蛋白水平作为连续变量进行分析时，也得到了类似的结果（p = 0.019）。
术前低白蛋白血症是CD患者肠切除一期吻合术后发生IASCs的重要预测因素。良好的术前营养状况可能降低IASCs的风险。
The aim of this study was to evaluate the impact of preoperative hypoalbuminemia on the development of intra-abdominal septic complications (IASCs) after primary anastomosis for patients with Crohn’s disease (CD). All CD patients undergoing bowel resection with a primary anastomosis during the study period from 2007 to 2015 were enrolled. The association of preoperative hypoalbuminemia (<30 g/L) with the risk for IASCs were assessed using both univariate and multivariate analyses. A total of 124 eligible patients were included, 117 (94.4%) of whom had available preoperative albumin level. Preoperative hypoalbuminemia occurred in 13 (11.7%) patients. The duration from diagnosis to surgery was longer for patients with preoperative hypoalbuminemia than those without (p = 0.012). Patients with preoperative hypoalbuminemia were more likely to have a history of preoperative use of 5-aminosalicylic acid (p = 0.013) and have an intraoperative finding of small bowel obstruction (p = 0.015). Of all patients, 24 (19.4%) developed postoperative IASCs. Univariate analysis showed that patients with preoperative hypoalbuminemia had an increased risk for IASCs (p = 0.012). Multivariate analysis confirmed the association between preoperative hypoalbuminemia and IASCs (odds ratio 4.67, 95% confidence interval: 1.28–17.04, p = 0.02). Similar findings were also obtained when preoperative albumin level was analysed as a continuous variable (p = 0.019). Preoperative hypoalbuminemia is a significant predictor for the development of postoperative IASCs in CD patients after bowel resection with a primary anastomosis. Favorable preoperative nutrition status might lessen the risk for IASCs.
登录
查看更多内容
影响因子：
4.9
作者：
Nisar, Pasha J.;Appau, Kweku A.;Kiran, Ravi P.
通讯作者：
Kiran, Ravi P.
影响因子：
3.9
作者：
Alves, Arnaud;Panis, Yves;Valleur, Patrice
通讯作者：
Valleur, Patrice
影响因子：
2.8
作者：
Iesalnieks, Igors;Kilger, Alexandra;Agha, Ayman
通讯作者：
Agha, Ayman
DOI：
10.1080/07315724.2000.10718954
发表时间：
2000-10-01
影响因子：
3.5
作者：
Sacks, GS;Dearman, K;Canada, T
通讯作者：
Canada, T
术前单纯肠内营养可减少瘘管性克罗恩病术后脓毒症并发症
影响因子：
4.7
作者：
Li, G.;Ren, J.;Li, J.
通讯作者：
Li, J.