Melanoma in African-Americans: Trends in biological behavior and clinical characteristics over two decades
Melanoma in African-Americans: Trends in biological behavior and clinical characteristics over two decades
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DOI：
10.1002/jso.1116
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发表时间：
2001-09-01
影响因子：
2.5
通讯作者：
Beech, DJ
中科院分区：
文献类型：
--
作者：
Bellows, CF;Belafsky, P;Beech, DJ
背景：黑色素瘤在美国的发病率正在上升。关于这种疾病的数据在非洲裔American.Methods稀疏：图表审查1975年至1997年在新奥尔良慈善医院（CHNO）诊断为黑色素瘤的患者。年龄，性别，解剖分布。组织学，提出阶段，生存，和种族进行了evaluated.Results：四十四198例非裔美国人，其中大多数开发皮肤黑色素瘤的足肢端表面。非裔美国男性出现皮肤病变的可能性是非裔美国女性的四倍。非裔美国人皮肤病变患者的中位生存期为45个月，而白人患者的中位生存期为135个月，白人患者出现早期疾病的可能性是非裔美国人的3.6倍（P < 0.05）。TNM分期在介绍，溃疡是显着的，独立的因素与一个更糟糕的结果在African-American.Conclusion：总生存时间为非洲裔美国人皮肤黑色素瘤是显着短于白种人与这种疾病。这种趋势可能是由于非洲裔美国人患有晚期疾病。提高患者和卫生保健提供者的认识水平对于在疾病的早期阶段识别患有黑色素瘤的非洲裔美国人并提高生存率是必要的。(C)2001 Wiley-Liss，Inc.
Background: The incidence of melanoma in the United States is increasing. Data on this disease in African-Americans is sparse.Methods: Chart review Of patients diagnozed with melanoma from 1975 to 1997 at Charity Hospital New Orleans (CHNO). Age, gender, anatomic distribution. histology, presenting stage, survival, and race were evaluated.Results: Forty-four of 198 patients were African-American, of whom the majority developed cutaneous melanoma on the acral surface of the foot. African-American males were four times more likely to present with a cutaneous lesion than were African-American females. The median survival time for African-American with cutaneous lesions was 45 months, compared to 135 months for caucasians who were 3.6 times more likely to present with early disease (P < 0.05). TNM stage at presentation, and ulceration were significant, independent factors associated with a worse outcome in African-Americans.Conclusion: Overall survival time for African-Americans with cutaneous melanoma is significantly shorter than for caucasians with this disease. This trend may be attributable to the fact that African-Americans present with advanced disease. An increased level of awareness among both patients and health-care providers is necessary to identify African-Americans with melanoma at earlier stages of disease and to improve survival. (C) 2001 Wiley-Liss, Inc.