Clearance of influenza virus infections by T cells: risk of collateral damage?
Clearance of influenza virus infections by T cells: risk of collateral damage?
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DOI：
10.1016/j.coviro.2013.05.002
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发表时间：
2013-08-01
影响因子：
5.9
通讯作者：
Kreijtz, J. H. C. M.
中科院分区：
文献类型：
--
作者：
Hillaire, M. L. B.;Rimmelzwaan, G. F.;Kreijtz, J. H. C. M.
甲型流感病毒是人类呼吸道感染的主要原因。为了预防流感，疫苗主要旨在诱导针对这两种表面蛋白的抗体，而不能预防来自其他亚型的甲型流感病毒。异亚型免疫是目前研究的热点之一，其中CD8和CD4 T细胞能够识别保守的IAV抗原表位，在甲型流感病毒感染过程中发挥重要作用。T细胞反应受到严格调控，以避免由于过度反应而造成的附带损害。不同的研究表明，对流感病毒感染的异常T细胞反应可能是有害的，并可能导致免疫病理学。在这里，我们讨论了最近的研究结果之间的平衡流感病毒感染的T细胞反应的有益和有害的影响。
Influenza A viruses are a major cause of respiratory infections in humans. To protect against influenza, vaccines mainly aim at the induction of antibodies against the two surface proteins and do not protect against influenza A viruses from other subtypes. There is an increasing interest in heterosubtypic immunity that does protect against different subtypes.CD8 and CD4 T cells have a beneficial effect on the course of influenza A virus infection and can recognize conserved IAV epitopes. The T cell responses are tightly regulated to avoid collateral damage due to overreaction. Different studies have shown that an aberrant T cell response to an influenza virus infection could be harmful and could contribute to immunopathology. Here we discuss the recent findings on the balance between the beneficial and detrimental effects of T cell responses in influenza virus infections.