Experimental and clinical experience with tissue engineering techniques for urethral reconstruction
Experimental and clinical experience with tissue engineering techniques for urethral reconstruction
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DOI：
10.1016/s0094-0143(02)00033-2
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发表时间：
2002-05-01
影响因子：
2.4
通讯作者：
Atala, A
中科院分区：
文献类型：
--
作者：
Atala, A
组织工程学已被认为是重建尿路的一种策略。这可能只涉及基质，其中身体的自然再生能力被用来定向或指导新组织的生长，或者使用基质和细胞。来自供体膀胱粘膜下层的脱细胞胶原基质在本中心的实验和临床应用中均取得了良好的效果。如果需要管状化的尿道修复，使用胶原基质上的细胞对于充分的组织形成是必不可少的。组织工程技术在尿路重建中是有用的。
Tissue engineering has been proposed as a strategy for urethral reconstruction. This may involve matrices alone, wherein the body's natural ability to regenerate is used to orient or direct new tissue growth, or the use of matrices with cells. Acellular collagen matrices derived from donor bladder submucosa have been used both experimentally and clinically for onlay urethral replacement with good success at our center. If a tubularized urethral repair is needed, the use of cells on the collagen matrix is essential for adequate tissue formation. Tissue engineering techniques are useful for urethral reconstruction.