Making Moco: A Personal History.

Making Moco: A Personal History.
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DOI:
10.3390/molecules28217296
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发表时间:
2023-10-27
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
Burgmayer SJN
Burgmayer SJN
中科院分区:
其他
文献类型:
--
作者:
Burgmayer SJN

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这篇文章描述了我近40年来探索了解与钼和钨离子在各自的酶中配位的特殊配体的道路。通过这次探索,我的目标是发现为什么大自然不是简单地在二硫杂环烯上使用甲基来螯合钼和钨,而是选择了一种复杂的吡喃喋呤。我的旅程通过合成模型钼化合物寻求答案,该模型化合物允许系统地研究钼与蝶呤、钼与蝶呤-二硫戊烯之间的相互作用,并揭示了与钼结合的吡喃喋呤二硫烯络合物的特殊特征。
This contribution describes the path of my nearly forty-year quest to understand the special ligand coordinated to molybdenum and tungsten ions in their respective enzymes. Through this quest, I aimed to discover why nature did not simply use a methyl group on the dithiolene that chelates Mo and W but instead chose a complicated pyranopterin. My journey sought answers through the synthesis of model Mo compounds that allowed systematic investigations of the interactions between molybdenum and pterin and molybdenum and pterin-dithiolene and revealed special features of the pyranopterin dithiolene chelate bound to molybdenum.
DOI: 10.1016/s0277-5387(00)84932-3
发表时间: 1986-01-01
期刊: POLYHEDRON
影响因子: 2.6
作者:
COUCOUVANIS, D;HADJIKYRIACOU, A;ILEPERUMA, O
通讯作者: ILEPERUMA, O
DOI: 10.1021/acs.inorgchem.2c01234
发表时间: 2022-09-05
影响因子: 4.6
作者:
Gates, Cassandra;Varnum, Haley;Getty, Catherine;Loui, Natalie;Chen, Ju;Kirk, Martin L.;Yang, Jing;Burgmayer, Sharon J. Nieter
通讯作者: Burgmayer, Sharon J. Nieter
DOI: 10.1038/nsb969
发表时间: 2003-09-01
期刊: NATURE STRUCTURAL BIOLOGY
影响因子: --
作者:
Bertero, MG;Rothery, RA;Strynadka, NCJ
通讯作者: Strynadka, NCJ
DOI: 10.1021/ic00217a049
发表时间: 1985-01-01
影响因子: 4.6
作者:
BURGMAYER, SJN;TEMPLETON, JL
通讯作者: TEMPLETON, JL