Cardiovascular Disease-Related Pregnancy Complications Are Associated with Increased Maternal Levels and Trajectories of Cardiovascular Disease Biomarkers During and After Pregnancy
Cardiovascular Disease-Related Pregnancy Complications Are Associated with Increased Maternal Levels and Trajectories of Cardiovascular Disease Biomarkers During and After Pregnancy
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DOI：
10.1089/jwh.2018.7560
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发表时间：
2020-01-14
影响因子：
3.5
通讯作者：
Epel, Elissa
中科院分区：
文献类型：
--
作者：
Parikh, Nisha, I;Laria, Barbara;Epel, Elissa
背景：妊娠合并妊娠期高血压疾病（HDP）和/或婴儿过小或早产会增加妇女日后患心血管疾病（CVD）的风险。尚不确定是否较高的母体CVD风险因素（通过围产期CVD生物标志物水平的增加反映）导致了这种风险，或者是否经历了复杂的妊娠本身增加了女性CVD风险（通过从妊娠早期到产后生物标志物轨迹的增加反映）。方法：我们对110名孕妇进行了为期8周的正念饮食和减压干预的二次分析。我们使用混合线性回归分析来比较有和没有CVD相关妊娠并发症（包括妊娠高血压或先兆子痫）或胎龄较小的妇女之间的CVD生物标志物水平和轨迹。
Background: Having a pregnancy complicated by hypertensive disorders of pregnancy (HDP) and/or having a small or preterm baby put a woman at risk for later cardiovascular disease (CVD). It is uncertain if higher maternal CVD risk factors (reflected by increased peripartum CVD biomarker levels) account for this risk, or if experiencing a complicated pregnancy itself increases a woman's CVD risk (reflected by an increase in biomarker trajectories from early pregnancy to postpartum). Methods: We conducted a secondary analysis of an 8-week mindful eating and stress reduction intervention in 110 pregnant women. We used mixed linear regression analysis to compare CVD biomarker levels and trajectories, between women with and without a CVD-related pregnancy complication (including HDP [gestational hypertension or preeclampsia] or having a small for gestational age [