Meniscectomy leads to an early increase in subchondral bone plate thickness in the rabbit knee
Meniscectomy leads to an early increase in subchondral bone plate thickness in the rabbit knee
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DOI：
10.1080/00016470310017758
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发表时间：
2003-08-01
期刊：
影响因子：
--
通讯作者：
Aspenberg, P
中科院分区：
文献类型：
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作者：
Fahlgren, A;Messner, K;Aspenberg, P
我们评估了兔模型半月板切除术后胫骨的形态变化。对 15 只兔子进行右膝内侧半月板切除术和左膝假手术。术后 13、25 和 40 周评估软骨下骨板和下方骨小梁的组织形态学参数。 5只兔子作为未手术对照。15只兔子中有13只半月板切除的膝关节软骨下骨板比假手术的对侧膝关节厚(p=0.01)，但骨小梁没有形态学差异。这些兔子的半月板切除膝盖出现了轻度骨关节炎，这可能部分是由于增厚的软骨下骨板的机械性能的变化所致。我们的研究结果表明，半月板切除术后的第一个骨反应发生在软骨下骨板而不是骨小梁中。
We evaluated morphological changes in the tibial bone after meniscectomy in a rabbit model. 15 rabbits subjected to a medial meniscectomy in the right knee and a sham-operation in the left. Histomorphometric parameters were evaluated in the subchondral bone plate and the underlying trabecular bone, 13, 25 and 40 weeks after surgery. 5 rabbits were used as unoperated controls.Meniscectomized knees had a thicker subchondral bone plate than sham-operated contralateral ones in 13 of the 15 rabbits (p=0.01), but the trabecular bone showed no morphological differences. The meniscectomized knees of these rabbits developed mild osteoarthrosis, described elsewhere, which may have been partly due to a change in the mechanical properties of the thickened subchondral bone plate.Our findings suggest that the first bony response after meniscectomy occurs in the subchondral bone plate rather than in the trabecular bone.