Association of obesity with cognitive function and brain structure in patients with major depressive disorder
Association of obesity with cognitive function and brain structure in patients with major depressive disorder
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DOI：
10.1016/j.jad.2017.08.028
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发表时间：
2018-01-01
影响因子：
6.6
通讯作者：
Kunugi, Hiroshi
中科院分区：
文献类型：
--
作者：
Hidese, Shinsuke;Ota, Miho;Kunugi, Hiroshi
背景：肥胖与抑郁症的病理生理学有关，这促使我们研究肥胖与抑郁症患者认知功能和脑结构的可能联系。方法：307名抑郁症患者和294名健康受试者，年龄、性别、民族(日本人)和利手(右)相匹配。认知功能评定采用简明精神分裂症认知评定量表(BACS)。使用基于体素的形态测量和扩散张量成像对114例患者的灰质和白质结构进行分析。结果：MDD患者的言语记忆、工作记忆、运动速度、注意力、执行功能和BACS综合评分低于健康受试者(p<；0.05)。在患者组中，肥胖患者(体重指数=30，n=17)的工作记忆、运动速度、执行功能和BACS综合评分低于非肥胖患者(n=290，p<；0.05，校正后)。与非肥胖组(n=107，p<；0.05，校正后)相比，肥胖组(n=7)的额叶、颞叶、丘脑和海马体体积、内囊白质各向异性分数和左视神经辐射减少。限制：肥胖组样本量不是很大。结论：肥胖症患者认知功能下降，灰质体积减少，认知相关脑区白质完整性受损。
Background: Obesity has been implicated in the pathophysiology of major depressive disorder (MDD), which prompted us to examine the possible association of obesity with cognitive function and brain structure in patients with MDD.Methods: Three hundred and seven patients with MDD and 294 healthy participants, matched for age, sex, ethnicity (Japanese), and handedness (right) were recruited for the study. Cognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS). Gray and white matter structures were analyzed using voxel-based morphometry and diffusion tensor imaging in a subsample of patients (n = 114) whose magnetic resonance imaging (MRI) data were obtained using a 1.5 T MRI system.Results: Verbal memory, working memory, motor speed, attention, executive function, and BACS composite scores were lower for the MDD patients than for the healthy participants (p < 0.05). Among the patient group, working memory, motor speed, executive function, and BACS composite scores were lower in obese patients (body mass index = 30, n = 17) than in non-obese patients (n = 290, p < 0.05, corrected). MRI determined frontal, temporal, thalamic, and hippocampal volumes, and white matter fractional anisotropy values in the internal capsule and left optic radiation were reduced in obese patients (n = 7) compared with non-obese patients (n = 107, p < 0.05, corrected).Limitations: Sample size for obese population was not very large.Conclusions: Obesity is associated with decreased cognitive function, reduced gray matter volume, and impaired white matter integrity in cognition-related brain areas in patients with MDD.