EXPRESSION OF A DELTA-HOMOLOG IN PROSPECTIVE NEURONS IN THE CHICK
EXPRESSION OF A DELTA-HOMOLOG IN PROSPECTIVE NEURONS IN THE CHICK
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DOI：
10.1038/375787a0
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发表时间：
1995-06-29
期刊：
影响因子：
64.8
通讯作者：
ISHHOROWICZ, D
中科院分区：
文献类型：
--
作者：
HENRIQUE, D;ADAM, J;ISHHOROWICZ, D
作为配基的Delta基因的产物和作为受体的Notch基因的产物是侧向抑制信号通路的关键成分，该通路调节果蝇许多不同组织的详细模式(1-8)。特别是在神经发生过程中，神经前体通过表达Delta，抑制了邻近表达Notch的细胞对神经命运的依赖(5，9，10)。脊椎动物已知有几个Notch基因(11-14)，但它们的功能尚不清楚，它们的配体到目前为止还不清楚。在这里，我们鉴定并描述了一个小鸡Delta同系物，C-Delta-1。我们发现，C-Delta-1在神经发生期间的未来神经元中表达，因为新的细胞正在诞生，它们的命运也被决定了。我们来自小鸡的数据，结合来自非洲爪哇的平行证据，表明Delta/Notch信号机制及其在神经发生中的作用在脊椎动物中都是保守的。
THE product of the Delta gene, acting as ligand, and that of the Notch gene, acting as receptor, are key components in a lateral-inhibition signalling pathway that regulates the detailed patterning of many different tissues in Drosophila(1-8). During neurogenesis in particular, neural precursors, by expressing Delta, inhibit neighbouring Notch-expressing cells from becoming committed to a neural fate(5,9,10). Vertebrates are known to have several Notch genes(11-14), but their functions are unclear and their ligands hitherto unidentified. Here we identify and describe a chick Delta homologue, C-Delta-1. We show that C-Delta-1 is expressed in prospective neurons during neurogenesis, as new cells are being born and their fates decided. Our data from the chick, combined with parallel evidence from Xenopus(15), suggest that both the Delta/Notch signalling mechanism and its role in neurogenesis have been conserved in vertebrates.