Disseminated Superficial Actinic Porokeratosis: Genetic Aspects
Disseminated Superficial Actinic Porokeratosis: Genetic Aspects
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DOI：
10.1001/archderm.1969.01610220036006
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发表时间：
1969-04
影响因子：
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通讯作者：
D. Anderson;M. E. Chernosky
中科院分区：
文献类型：
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作者：
D. Anderson;M. E. Chernosky
对10个播散性浅表性光化性汗孔角化病（DSAP）家系进行了临床遗传学研究。对58名家庭成员进行了全面的皮肤检查。年龄显着影响DSAP的表现，没有观察到低于16岁的情况下，但在这个年龄后，频率几乎线性增加，随着年龄的增加。男性和女性之间的感染率，病变的多样性，和首次识别的年龄没有差异。遗传学结果表明DSAP是一种常染色体显性遗传，在年轻的时候减少的等位基因频率。没有证据表明DSAP基因位点与各种血型标记位点之间存在遗传连锁。
A clinicogenetic study was made of ten famlies with disseminated superficial actinic porokeratosis (DSAP). Complete cutaneous examinations were conducted on 58 family members. Age significantly influenced the manifestation of DSAP; no cases were observed below 16 years of age, but after this age the frequency increased almost linearly with an increase in age. No differences were noted between males and females in affection rate, multiplicity of lesions, and age at first recognition. Genetic results indicated DSAP to be inherited as an autosomal dominant with reduced penetrance at young ages. No evidence of genetic linkage was found between the gene locus for DSAP and various blood group marker loci.