Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells
Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells
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DOI：
10.1210/en.2003-0547
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发表时间：
2004-01-01
期刊：
影响因子：
4.8
通讯作者：
Magness, RR
中科院分区：
文献类型：
--
作者：
Chen, DB;Bird, IM;Magness, RR
雌激素给药后的快速子宫血管扩张被认为是通过内皮NO合酶（eNOS）介导的内皮产生一氧化氮（NO）。然而，雌激素激活子宫动脉内皮细胞（UAEC）中eNOS的机制尚不清楚。在这项研究中，我们观察到雌二醇-17 β（E2）和E2-BSA快速（
Rapid uterine vasodilatation after estrogen administration is believed to be mediated by endothelial production of nitric oxide (NO) via endothelial NO synthase (eNOS). However, the mechanism(s) by which estrogen activates eNOS in uterine artery endothelial cells (UAEC) is unknown. In this study, we observed that estradiol-17beta (E2) and E2-BSA rapidly (