Gamma interferon fails to induce expression of indoleamine 2,3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells
Gamma interferon fails to induce expression of indoleamine 2,3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells
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DOI：
10.1128/iai.70.5.2690-2693.2002
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发表时间：
2002-05-01
影响因子：
3.1
通讯作者：
McInnes, C
中科院分区：
文献类型：
--
作者：
Entrican, G;Wattegedera, S;McInnes, C
BeWo滋养层细胞系不组成型表达色氨酸降解酶吲哚胺2，3-双加氧酶（IDO），也不能由γ干扰素诱导IDO表达。这与BeWo细胞不能控制流产嗜衣原体的生长有关，与用γ干扰素处理的HeLa细胞中观察到的效果相反。
The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.