Myeloid Leukemias and Virally Induced Lymphomas in Miniature Inbred Swine: Development of a Large Animal Tumor Model.
Myeloid Leukemias and Virally Induced Lymphomas in Miniature Inbred Swine: Development of a Large Animal Tumor Model.
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DOI：
10.3389/fgene.2015.00332
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发表时间：
2015
影响因子：
3.7
通讯作者：
Huang CA
中科院分区：
文献类型：
--
作者：
Duran-Struuck R;Matar AJ;Huang CA
由于缺乏可移植的大动物肿瘤模型，限制了液体癌治疗新的治疗策略的研究。猪作为一个物种，基于它们与人类的相似性以及它们在生物医学研究中的广泛应用，提供了一个自然的选择。具体地说，马萨诸塞州总医院的小型猪群保留了独特的遗传特征，有助于造血细胞和实体器官移植的研究。在这些猪身上自发产生的液体癌，特别是髓系白血病和B细胞淋巴瘤，与人类的恶性肿瘤非常相似。从这些自然发生的恶性肿瘤体外建立侵袭性肿瘤细胞系的能力使可移植的肿瘤模型成为现实。在这里，我们讨论了我们在主要组织相容性特征的小型猪的髓系和淋巴系肿瘤方面的经验，以及未来发展大型动物可移植肿瘤模型的方法。
The lack of a large animal transplantable tumor model has limited the study of novel therapeutic strategies for the treatment of liquid cancers. Swine as a species provide a natural option based on their similarities with humans and their already extensive use in biomedical research. Specifically, the Massachusetts General Hospital miniature swine herd retains unique genetic characteristics that facilitate the study of hematopoietic cell and solid organ transplantation. Spontaneously arising liquid cancers in these swine, specifically myeloid leukemias and B cell lymphomas, closely resemble human malignancies. The ability to establish aggressive tumor cell lines in vitro from these naturally occurring malignancies makes a transplantable tumor model a close reality. Here, we discuss our experience with myeloid and lymphoid tumors in major histocompatibility characterized miniature swine and future approaches regarding the development of a large animal transplantable tumor model.