IS NEURONAL INTESTINAL DYSPLASIA (NID) A PRIMARY DISEASE OR A SECONDARY PHENOMENON
IS NEURONAL INTESTINAL DYSPLASIA (NID) A PRIMARY DISEASE OR A SECONDARY PHENOMENON
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DOI：
10.1055/s-2008-1063549
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发表时间：
1993-08-01
影响因子：
1.8
通讯作者：
HANIMANN, B
中科院分区：
文献类型：
--
作者：
SACHER, P;BRINER, J;HANIMANN, B
为了确定可能的潜在神经节细胞疾病，标本已采取新生儿和婴儿肠梗阻治疗1988年1月至1992年6月。3例肠畸形患者、2例新生儿肠梗阻患者、3例胎粪性腹膜炎患者、1例先天性巨结肠Duhamel根治术后持续性便秘患者和1例坏死性小肠结肠炎保守治疗后直肠狭窄患者均确诊为NID。此外，NID被发现在1例复发性脱垂的回肠造口。对于在剖腹手术中采集标本的患者，通过额外的直肠抽吸活检排除了相关的先天性巨结肠。NID的发展在以前的正常肠道，NID与肠道畸形的关联，以及目前的系列NID患者的临床异质性表明，NID是先天性梗阻因素或炎症性疾病引起的神经肠系统的反应。
In order to identify possible underlying ganglion-cell disorders, specimens have been taken in neonates and infants with intestinal obstruction treated between January 1988 and June 1992. NID was confirmed in 3 patients with intestinal malformation, 2 patients with neonatal intestinal obstruction, 3 patients with meconium peritonitis, 1 patient with persistent constipation after Duhamel's pull-through for Hirschsprung's disease and 1 patient with rectal stricture after conservative treatment for necrotising enterocolitis. Additionally, NID was found in 1 patient with recurrent prolapse of an ileostomy. Associated Hirschsprung's disease has been ruled out by additional rectal suction biopsies in patients where specimens have been collected at laparotomy first. Development of NID in previous normal bowel, the association of NID with intestinal malformations as well as the clinical heterogenity of patients with NID of the present series suggest that NID is a reaction of the neural intestinal system caused by congenital obstructive factors or inflammatory diseases.