A special healing pattern in stable metaphyseal fractures.
A special healing pattern in stable metaphyseal fractures.
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稳定干骺端骨折的特殊愈合模式
DOI：
10.3109/17453674.2014.1003127
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发表时间：
2015-04
影响因子：
3.7
通讯作者：
Jiang BG
中科院分区：
文献类型：
--
作者：
Chen WT;Han da C;Zhang PX;Han N;Kou YH;Yin XF;Jiang BG
干骺端骨折愈合速度快，与骨干愈合过程不同。动物研究主要集中在骨干骨折上。我们研究了兔干骺端骨折愈合过程。60只家兔（分为12组）行胫骨近端截骨、解剖复位、螺钉固定。术后不同时间点取胫骨近端进行组织学检查。术后2周未见明显的骨坏死和骨吸收。从第5天到第5周，编织骨或新的小梁形成。从第2周开始，骨重塑为板层骨，并在第6周达到高峰。这三个阶段是重叠的。组织形态测量显示，结构呈单峰曲线变化。干骺端骨折的愈合过程似乎不同于通常研究的干骺端骨折的愈合过程。它是一个快速的过程，可分为4个组织学阶段：细胞活化和分化、编织骨形成、编织骨向板层骨转化和进一步重塑。
Metaphyseal fractures heal in a rapid fashion that is different from the bone shaft healing process. Animal studies have focused on diaphyseal fractures. We investigated the metaphyseal fracture-healing process in rabbits. 60 rabbits (divided into 12 groups) underwent proximal tibial osteotomy, anatomical reduction, and fixation with screws. After surgery, the proximal tibiae were harvested at different time points for histology. No obvious osteonecrosis or bone resorption were found 2 weeks after surgery. From day 5 to week 5, woven bone or new trabeculae formed. From week 2, remodeling into lamellar bone started and reached a peak at week 6. These 3 stages overlapped. Histomorphometry showed that the structure changed as a unimodal curve. The healing process of metaphyseal fractures appears to differ from the commonly studied healing process in diaphyseal fractures. It is rapid, and can be divided into 4 histological stages: cellular activation and differentiation, formation of woven bone, transformation of woven bone into lamellar bone, and further remodeling.