VALIDATION OF A CLINICAL ANTISACCADIC EYE-MOVEMENT TEST IN THE ASSESSMENT OF DEMENTIA
VALIDATION OF A CLINICAL ANTISACCADIC EYE-MOVEMENT TEST IN THE ASSESSMENT OF DEMENTIA
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DOI：
10.1001/archneur.1991.00530180102024
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发表时间：
1991-06-01
影响因子：
--
通讯作者：
MARUFF, P
中科院分区：
文献类型：
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作者：
CURRIE, J;RAMSDEN, B;MARUFF, P
产生反视动的能力（眼球运动故意在与视觉刺激相反的方向上进行）可用于评估各种神经系统和精神疾病的中枢神经系统功能。 然而，这种模式在临床实践中的有用性是有限的眼电实验室的需要。 我们描述了这样一个antisaccadic任务的临床版本，并提出了332名受试者的规范性数据。 我们还检查了30例阿尔茨海默病患者、5例亨廷顿病患者和12例假性痴呆患者的临床抗accades和认知表现。 在阿尔茨海默氏病中，临床抗accadic测试的错误率与同一天通过红外眼电图测量的实验室抗accadic任务的错误率相关性很好，证实了临床抗accadic测试是更复杂的实验室范例的有效模拟。 临床抗accadic错误率与阿尔茨海默病痴呆的严重程度密切相关，与认知表现的相关性表明，临床抗accadic测试可能对额叶功能障碍有一定的特异性。 假性痴呆患者有正常的临床抗accadic错误率，因此该测试可能用于区分痴呆和假性痴呆。 这种临床antisaccadic测试提供了一个简单，可靠，廉价的定量临床工具，是在评估更高的皮质功能障碍的价值。
The ability to generate antisaccades (eye movements deliberately made in the direction opposite to that of a visual stimulus) may be used to assess central nervous system function in a variety of neurologic and psychiatric disorders. However, the usefulness of this paradigm in clinical practice is limited by the need for an oculographic laboratory. We describe a clinical version of such an antisaccadic task and present normative data from 332 subjects. We also examined clinical antisaccades and cognitive performance in 30 patients with Alzheimer's disease, five patients with Huntington's disease, and 12 patients with pseudodementia. In Alzheimer's disease, error rates in the clinical antisaccadic test correlated well with those from a laboratory-based antisaccadic task measured on the same day by infrared oculography, confirming that the clinical antisaccadic test is a valid analog of the more sophisticated laboratory paradigms. Clinical antisaccadic error rates correlated strongly with the severity of dementia in Alzheimer's disease, and correlations with cognitive performance suggested that the clinical antisaccadic test may have some specificity for frontal lobe dysfunction. Patients with pseudodementia had normal clinical antisaccadic error rates, and the test may therefore be of use in differentiating dementia from pseudodementia. This clinical antisaccadic test provides a simple, reliable, and inexpensive quantitative clinical tool that is of value in the assessment of disturbances of higher cortical function.