Early sensory processing in right hemispheric stroke patients with and without extinction
Early sensory processing in right hemispheric stroke patients with and without extinction
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DOI：
10.1016/j.neuropsychologia.2015.05.011
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发表时间：
2015-07-01
期刊：
影响因子：
2.6
通讯作者：
Karnath, Hans-Otto
中科院分区：
文献类型：
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作者：
de Haan, Bianca;Stoll, Tine;Karnath, Hans-Otto
虽然灭绝最常被视为注意力障碍，而不是作为一个失败的结果处理对侧病变的感觉信息，它已被推测，在灭绝患者对侧病变的目标的早期感觉处理可能不完全正常。我们使用了一个掩蔽的视觉运动反应启动范式，研究了对侧病灶和同侧病灶的外周阈下启动刺激对中枢目标性能的影响，使我们能够比较与这些启动刺激相关的早期感觉加工的强度与右脑损伤患者和健康老年人之间的灭绝以及。我们发现，一个信息的阈下启动在左侧contralesional视野对中央目标性能的影响显着降低，在右脑损伤患者和不灭绝。结果表明，一个低水平的早期感觉恶化的神经代表性contralesional启动刺激是一个普遍的后果，右半球脑损伤无关的存在或不存在的灭绝。这表明，存在的空间偏见对contralesional信息是不足以引起灭绝。要使灭绝发生，这种空间偏向可能需要伴随着注意力能力的病理性（非方向性）降低。(C)2015爱思唯尔有限公司版权所有。
While extinction is most commonly viewed as an attentional disorder and not as a consequence of a failure to process contralesional sensory information, it has been speculated that early sensory processing of contralesional targets in extinction patients might not be fully normal. We used a masked visuo-motor response priming paradigm to study the influence of both contralesional and ipsilesional peripheral subliminal prime stimuli on central target performance, allowing us to compare the strength of the early sensory processing associated with these prime stimuli between right brain damaged patients with and without extinction as well as healthy elderly subjects. We found that the effect of an informative subliminal prime in the left contralesional visual field on central target performance was significantly reduced in both right brain damaged patients with and without extinction. The results suggest that a low-level early sensory deterioration of the neural representation for contralesional prime stimuli is a general consequence of right hemispheric brain damage unrelated to the presence or absence of extinction. This suggests that the presence of a spatial bias against contralesional information is not sufficient to elicit extinction. For extinction to occur, this spatial bias might need to be accompanied by a pathological (non-directional) reduction of attentional capacity. (C) 2015 Elsevier Ltd. All rights reserved.