IVIM Diffusion-weighted Imaging of the Liver at 3.0T: Comparison with 1.5T.
IVIM Diffusion-weighted Imaging of the Liver at 3.0T: Comparison with 1.5T.
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DOI：
10.1016/j.ejro.2015.08.001
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发表时间：
2015
影响因子：
2
通讯作者：
Taouli B
中科院分区：
文献类型：
--
作者：
Cui Y;Dyvorne H;Besa C;Cooper N;Taouli B
比较 1.5 T 和 3.0 T 之间肝脏体素不相干运动 (IVIM) 扩散加权成像 (DWI) 的参数量化和平台间再现性。在这项 IRB 批准的前瞻性研究中，19 名受试者（17 名慢性肝病患者和 2 名健康志愿者）在 1.5 T 和 3.0 T 下接受了两次重复扫描。每次扫描均包括 IVIM DWI，使用 0 至 800 s/mm2 的 16 个 b 值。一名观察者测量了每个平台的 IVIM 参数，并估计了 b0、200、400 和 800 s/mm2 的信噪比 (eSNR)。 Wilcoxon 配对检验用于比较肝脏 eSNR 和 IVIM 参数。通过计算受试者内变异系数（CV）和 Bland-Altman 一致性极限来评估平台间的再现性。使用冰水模型来测试两个 MRI 系统之间的 ADC 变异性。两个平台之间 ADC 的平均体外差异为 6.8%。除 b0 (p = 0.239) 外，所有选定的 b 值在 3.0T 时 eSNR 均显着较高 (p = 0.006–0.020)。肝脏 IVIM 参数在 1.5 T 和 3.0 T 之间显着不同 (p = 0.005–0.044)，ADC 除外 (p = 0.748)。真实扩散系数 (D) 和 ADC 的平台间重现性良好，平均 CV 分别为 10.9% 和 11.1%。灌注分数 (PF) 和伪扩散系数 (D*) 显示出更有限的平台间再现性（PF 的平均 CV 为 22.6%，D* 的平均 CV 为 46.9%）。肝脏 D 和 ADC 值在 1.5 T 和 3.0 T 平台之间表现出良好的重现性；而两个平台之间的 PF 变化较大，D* 参数变化较大。这些发现可能对评估 IVIM DWI 在肿瘤反应和肝纤维化中的作用的药物试验有影响。
To compare intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) of the liver between 1.5 T and 3.0 T in terms of parameter quantification and inter-platform reproducibility. In this IRB approved prospective study, 19 subjects (17 patients with chronic liver disease and 2 healthy volunteers) underwent two repeat scans at 1.5 T and 3.0 T. Each scan included IVIM DWI using 16 b values from 0 to 800 s/mm2. A single observer measured IVIM parameters for each platform and estimated signal to noise ratio (eSNR) at b0, 200, 400 and 800 s/mm2. Wilcoxon paired tests were used to compare liver eSNR and IVIM parameters. Inter-platform reproducibility was assessed by calculating within-subject coefficient of variation (CV) and Bland–Altman limits of agreement. An ice water phantom was used to test ADC variability between the two MRI systems. The mean invitro difference in ADC between the two platforms was 6.8%. eSNR was significantly higher at 3.0T for all selected b values (p = 0.006–0.020), except for b0 (p = 0.239). Liver IVIM parameters were significantly different between 1.5 T and 3.0 T (p = 0.005–0.044), except for ADC (p = 0.748). The inter-platform reproducibility of true diffusion coefficient (D) and ADC were good, with mean CV of 10.9% and 11.1%, respectively. Perfusion fraction (PF) and pseudodiffusion coefficient (D*) showed more limited inter-platform reproducibility (mean CV of 22.6% for PF and 46.9% for D*). Liver D and ADC values showed good reproducibility between 1.5 T and 3.0 T platforms; while there was more variability in PF, and large variability in D* parameters between the two platforms. These findings may have implications for drug trials assessing the role of IVIM DWI in tumor response and liver fibrosis.