Protein aspartate phosphatases control the output of two-component signal transduction systems.
Protein aspartate phosphatases control the output of two-component signal transduction systems.
复制标题
蛋白质天冬氨酸磷酸酶控制双组分信号转导系统的输出。
DOI：
10.1016/0168-9525(96)81420-x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Hoch,JA
中科院分区：
文献类型：
--
作者：
Perego,M;Hoch,JA
天冬氨酸的磷酸化或去磷酸化调节双组分信号系统的反应调节剂的输出活性。这些系统中的信号输入依赖于信号转导激酶，其可以响应于各种信号配体，并且在某些情况下，响应于小的磷酸化代谢中间体。许多双组分信号传导系统的激酶组分也显示响应调节剂-磷酸磷酸酶活性，其响应信号使响应调节剂失活。新发现的激酶非依赖性磷酸酶允许额外的信号来影响反应调节剂磷酸化的程度。这种磷酸酶在控制复杂过程的信号转导系统中普遍存在，例如微生物发育的起始。
Phosphorylation or dephosphorylation of an aspartate regulates the output activity of the response regulator of two-component signaling systems. Signal input in these systems is dependent on signal-transducing kinases, which can respond to a variety of signal ligands and, in some cases, to small phosphorylated metabolic intermediates. The kinase component of many two-component signaling systems also displays a response regulator-phosphate phosphatase activity that inactivates the response regulator in response to signals. Newly discovered kinase-independent phosphatases allow additional signals to influence the extent of response-regulator phosphorylation. Such phosphatases are prevalent in signal transduction systems controlling complex processes, such as the initiation of development in microorganisms.