Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells
Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells
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DOI：
10.1007/s10038-007-0228-0
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发表时间：
2008-02-01
影响因子：
3.5
通讯作者：
Nakai, Kenta
中科院分区：
文献类型：
--
作者：
Hatada, Izuho;Morita, Sumiyo;Nakai, Kenta
包括DNA甲基化在内的表观遗传调控在多种分化过程中起着重要作用。我们使用一种称为迈阿密的基于微阵列的方法分析了P19胚胎癌细胞神经分化中的DNA甲基化。我们发现了基因组范围内的去甲基化。这表明去甲基化而不是甲基化在神经分化中是重要的。
Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.