Non-Alcoholic Fatty Liver Disease Is Associated with an Increased Incidence of Atrial Fibrillation in Patients with Type 2 Diabetes
Non-Alcoholic Fatty Liver Disease Is Associated with an Increased Incidence of Atrial Fibrillation in Patients with Type 2 Diabetes
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DOI：
10.1371/journal.pone.0057183
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发表时间：
2013-02-22
期刊：
影响因子：
3.7
通讯作者：
Byrne, Christopher D.
中科院分区：
文献类型：
--
作者：
Targher, Giovanni;Valbusa, Filippo;Byrne, Christopher D.
背景：2型糖尿病患者非酒精性脂肪性肝病（NAFLD）与房颤（AF）之间的关系目前尚不清楚。我们研究了NAFLD和2型糖尿病患者AF事件风险之间的关系。方法和结果：我们前瞻性地随访了10年的随机样本400例2型糖尿病患者，他们在基线时没有AF。每年进行一次标准的12导联心电图检查，由一名心脏病专家对受影响的参与者进行房颤诊断。在基线时，NAFLD是通过在没有其他肝脏疾病的情况下超声检测肝脏脂肪变性来定义的。在10年的随访期间，有42例（10.5%）AF事件。NAFLD与AF发生风险增加相关（比值比[OR] 4.49，95%CI 1.6-12.9，p
Background: The relationship between non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) in type 2 diabetes is currently unknown. We examined the relationship between NAFLD and risk of incident AF in people with type 2 diabetes.Methods and Results: We prospectively followed for 10 years a random sample of 400 patients with type 2 diabetes, who were free from AF at baseline. A standard 12-lead electrocardiogram was undertaken annually and a diagnosis of incident AF was confirmed in affected participants by a single cardiologist. At baseline, NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other liver diseases. During the 10 years of follow-up, there were 42 (10.5%) incident AF cases. NAFLD was associated with an increased risk of incident AF (odds ratio [OR] 4.49, 95% CI 1.6-12.9, p