Cytogenetical observations in two cases of polymorphous low-grade adenocarcinoma of the salivary glands.
Cytogenetical observations in two cases of polymorphous low-grade adenocarcinoma of the salivary glands.
复制标题
两例唾液腺多形性低级别腺癌的细胞遗传学观察。
DOI：
10.1016/b978-0-444-59426-6.00009-4
复制
发表时间：
1992
影响因子：
2
通讯作者：
I. Melén
中科院分区：
文献类型：
--
作者：
Joachim Mark;R. Dahlenfors;Göran Stenman;M. Bende;I. Melén
报告两例培养涎腺多形性低级别腺癌(PLGA)的细胞遗传学结果。第一例PLGA是腮腺多形性腺瘤以外的癌。这是一种以广泛而复杂的结构重排为特征的假二倍体干系。染色体检查结果显示与之前研究的唯一一例PLGA(也是腮腺多形性腺瘤以外的癌)的发现有许多相似之处。两者的结果都可以与混合瘤的典型异常相吻合。报道的第二个PLGA来自一个小唾液腺。它展示了一幅完全不同的图景，其特点是亚二倍体，几乎完全是数字的变异，以及仅以单体22为特征的茎系的出现。病因学差异被认为是两种类型PLGA之间细胞遗传学差异的一种可能解释。
The cytogenetical findings in two cases of cultured salivary polymorphous low-grade adenocarcinoma (PLGA) are reported. The first PLGA was a carcinoma ex pleomorphic adenoma of the parotid gland. This had a pseudodiploid stemline characterized by extensive and complicated structural rearrangements. The chromosomal findings showed many similarities to those in the only previously studied case of PLGA (also a carcinoma ex pleomorphic adenoma of the parotid). The results in both could fit with abnormalities superimposed on those typical of mixed tumors. The second PLGA reported derived from a minor salivary gland. It showed a completely different picture, distinguished by a hypodiploid, almost exclusively numerical, variation and the occurrence of a stemline characterized by only monosomy 22. Etiological differences were proposed as one possible explanation for the cytogenetical differences between the two types of PLGA.