Temperature, not LuxS, mediates AI-2 formation in hydrothermal habitats
Temperature, not LuxS, mediates AI-2 formation in hydrothermal habitats
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DOI：
10.1111/j.1574-6941.2009.00662.x
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发表时间：
2009-04-01
影响因子：
4.2
通讯作者：
Kelly, Robert M.
中科院分区：
文献类型：
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作者：
Nichols, Jason D.;Johnson, Matthew R.;Kelly, Robert M.
群体感应为协调许多中温细菌的社区范围的微生物行为提供了基础。然而，很少有人注意到这种现象发生在极端高温的微生物环境中的可能性。尽管高温菌基因组中不存在LUX S，但通过生物反应和非生物反应相结合的步骤，可以由黑热菌和呋喃热球菌形成自身诱导物-2(AI-2)，它是一种硼化呋喃酮，并被认为是一种“通用的”种间中温细菌通讯信号。然而，AI-2没有在这些生物体中诱导出任何可检测到的群体感应表型，尽管基于转录组的证据表明AI-2诱导了Maritima的应激反应。AI-2在热液生境中的重要性(如果有的话)尚不清楚。然而，这些结果表明，考虑环境因素的重要性，在这种情况下，高温是生化和微生物现象的非生物致病因素。
Quorum sensing provides the basis for coordinating community-wide, microbial behaviors in many mesophilic bacteria. However, little attention has been directed toward the possibility that such phenomena occur in extremely thermal microbial environments. Despite the absence of luxS in hyperthermophile genomes, autoinducer-2 (AI-2), a boronated furanone and proposed 'universal' interspecies mesophilic bacterial communication signal, could be formed by Thermotoga maritima and Pyrococcus furiosus through a combination of biotic and abiotic reaction steps. AI-2 did not, however, induce any detectable quorum-sensing phenotypes in these organisms, although transcriptome-based evidence of an AI-2-induced stress response was observed in T. maritima. The significance, if any, of AI-2 in hydrothermal habitats is not yet clear. Nevertheless, these results show the importance of considering environmental factors, in this case high temperatures, as abiotic causative agents of biochemical and microbiological phenomena.