Chemical mutagen testing on in vivo somatic mammalian cells
Chemical mutagen testing on in vivo somatic mammalian cells
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DOI：
10.1007/bf01986538
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发表时间：
1973-06
期刊：
影响因子：
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通讯作者：
W. Schmid
中科院分区：
文献类型：
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作者：
W. Schmid
讨论了对体细胞进行体内细胞遗传学测试的可能性和局限性。对现有程序相对不敏感所引起的问题给予了特别关注。强调在计划筛查试验时，必须考虑到已知的染色体断裂化学品研究积累的经验；理论上的考虑不应凌驾于实际观察之上。附录中给出了微核试验的技术细节。此外，还对生殖细胞和胚胎的细胞遗传学检测提出了一些看法。
Possibilities and limitations in the use of in vivo cytogenetic tests on somatic cells are discussed. Special attention is focused on the problems raised by the relative insensivity of the available procedures. It is emphasized that in planning screening tests the accumulated experience from studies with known chromosome breaking chemicals must be taken into account; theoretical considerations should not override the actual observations. In the Appendix, technical details of the micronucleus test are given. Furthermore, some thoughts are expressed concerning cytogenetic testing on germ cells and embryos.