Nerve Growth Factor: Early Studies and Recent Clinical Trials.
Nerve Growth Factor: Early Studies and Recent Clinical Trials.
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神经生长因子：早期研究和最近的临床试验。
DOI：
10.2174/1570159x16666180412092859
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发表时间：
2018
影响因子：
5.3
通讯作者：
Aloe L
中科院分区：
文献类型：
--
作者：
Rocco ML;Soligo M;Manni L;Aloe L
自发现以来，神经生长因子（NGF）因其对周围和中枢神经系统神经细胞的存活、生长和分化的许多重要调节功能而长期以来在发育和成人神经生物学中占据着关键作用。 NGF 是神经营养因子家族中第一个被发现的成员，统称为神经营养因子（包括脑源性神经营养因子、神经营养因子 3 和神经营养因子 4/5）。 NGF 因其对选定的周围神经元群的存活和分化的作用而被发现。从那时起，人们进行了大量的基础研究和人体研究来探索纯化的 NGF 在防止 NGF 接受细胞死亡方面的作用。这些研究表明，局部给药后，NGF 对人类皮肤压疮、角膜溃疡、青光眼、视网膜黄斑病、视网膜色素变性以及小儿视神经胶质瘤和脑外伤具有重要的治疗特性。本综述的目的是介绍我们之前、最近和正在进行的关于 NGF 治疗特性的临床研究。
Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neuro-biology for its many important regulatory functions on the survival, growth and differentiation of nerve cells in the peripheral and central nervous system. NGF is the first discovered member of a family of neurotrophic factors, collectively indicated as neurotrophins, (which include brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin 4/5). NGF was discov-ered for its action on the survival and differentiation of selected populations of peripheral neurons. Since then, an enormous number of basic and human studies were undertaken to explore the role of purified NGF to prevent the death of NGF-receptive cells. These studies revealed that NGF possesses important therapeutic properties, after topical administration, on human cutaneous pressure ulcer, corneal ulcers, glaucoma, retinal maculopathy, Retinitis Pigmentosa and in pediatric optic gliomas and brain traumas. The aim of this review is to present our previous, recent and ongoing clinical studies on the ther-apeutic properties of NGF.