PROTEOGLYCANS IN EXPERIMENTAL INTERVERTEBRAL-DISK DEGENERATION
PROTEOGLYCANS IN EXPERIMENTAL INTERVERTEBRAL-DISK DEGENERATION
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DOI：
10.1097/00007632-198105000-00002
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发表时间：
1981-01-01
期刊：
影响因子：
3
通讯作者：
MUIR, H
中科院分区：
文献类型：
--
作者：
LIPSON, SJ;MUIR, H
通过腹侧核突出手术诱导的兔椎间盘退变动物模型产生椎间盘退变的形态学变化。组织学特征和蛋白多糖的变化已在脑疝形成后的不同时间进行了研究。损伤后，环形伤口边缘的细胞化生为纤维软骨，细胞增殖几乎将整个椎间盘空间变成纤维软骨。椎骨骨赘是通过软骨内骨化序列发生的。聚集蛋白多糖在退化早期有两个充满期。椎间盘的含水量在突出后的前两天迅速但仅短暂恢复，而椎间盘总蛋白聚糖含量的变化与这些变化平行。疝出后透明质酸含量迅速下降，但蛋白多糖单体的大小不随变性而改变。有人认为，受限流体力学的丧失标志着修复尝试失败，而不是蛋白多糖的生化变化引发了椎间盘退变。
An animal model of intervertebral disc degeneration induced surgically by ventral nuclear herniation in the rabbit produces morphologic changes of disc degeneration. Histologic characteristics and proteoglycan changes have been studied at various times after herniation. After injury, there was metaplasia into fibrocartilage originating from the cells along the margins of the annular wound, with proliferation of cells changing almost the entire disc space into fibrocartilage. A vertebral osteophyte occurred through an endochondral ossification sequence. Aggregating proteoglycans had two periods of repletion in the early course of degeneration. The water content of the disc was rapidly but only transiently restored in the first two days after herniation, whilst the changes in the total proteoglycan content of the disc paralleled these changes. Hyaluronic acid content decreased rapidly after herniation, but the size of the proteoglycan monomers did not change with degeneration. It is suggested that loss of confined fluid mechanics signals an abortive repair attempt rather than that the biochemical changes in proteoglycans initiate disc degeneration.