Interleukin‐17 gene polymorphisms are associated with bladder cancer in a chinese han population
Interleukin‐17 gene polymorphisms are associated with bladder cancer in a chinese han population
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DOI：
10.1002/mc.21928
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发表时间：
2013-11
影响因子：
4.6
通讯作者：
Bin Zhou;Peng Zhang;Yanyun Wang;Shaoqing Shi;Kui Zhang;H. Liao;Lin Zhang
中科院分区：
文献类型：
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作者：
Bin Zhou;Peng Zhang;Yanyun Wang;Shaoqing Shi;Kui Zhang;H. Liao;Lin Zhang
白细胞介素-17 (IL-17) 已被证明在炎症和自身免疫性疾病的发病机制中发挥重要作用，并且在多种类型的癌症中升高。本研究分析了IL-17基因多态性及其对膀胱癌发病机制的影响。 TaqMan® SNP 基因分型测定用于对 301 名膀胱癌患者和 446 名种族匹配的健康对照者的 IL-17A 的 SNP rs2275913 和 IL-17F 的 SNP rs763780 进行基因分型。膀胱癌患者中rs2275913的AA基因型和A等位基因以及rs763780的TT基因型和T等位基因的频率显着高于对照组，表明这两个SNP均与膀胱癌相关（P = 0.003，OR = 1.37，95% CI = 1.12–1.69 rs2275913 和 rs763780 等位基因 T 的 P = 0.018，OR = 1.46，95% CI = 1.07–2.00）。分层分析结果显示，rs2275913与男性、非吸烟者、膀胱癌侵袭相关，而rs763780与膀胱癌侵袭相关。我们的结果表明，IL-17A 的 SNP rs2275913 和 IL-17F 的 SNP rs763780 与膀胱癌的发生以及性别、吸烟状况和肿瘤分期相关。 © 2012 Wiley 期刊公司。
Interleukin‐17 (IL‐17) has been shown to play an important role in the pathogenesis of inflammation and autoimmune disorders, and to be elevated in several types of cancer. The present study analyzed polymorphisms in IL‐17 gene and their impact on the pathogenesis of bladder cancer. The TaqMan® SNP Genotyping Assay was used to genotype the SNP rs2275913 of IL‐17A and SNP rs763780 of IL‐17F in 301 bladder cancer patients and 446 ethnicity‐matched healthy controls. The frequencies of AA genotype and A allele of rs2275913, as well as TT genotype and T allele of rs763780 in the bladder cancer patients were significantly higher than that of controls, indicating that both of these two SNPs were associated with bladder cancer (P = 0.003, OR = 1.37, 95% CI = 1.12–1.69 for allele A of rs2275913, and P = 0.018, OR = 1.46, 95% CI = 1.07–2.00 for allele T of rs763780, respectively). Results of stratified analysis revealed that rs2275913 was associated with male, non‐smokers, and invasion of bladder cancer, while rs763780 was associated with invasion of bladder cancer. Our results suggested that the SNP rs2275913 of IL‐17A and SNP rs763780 of IL‐17F were associated with the development, as well as gender, smoking status and tumor stage of bladder cancer. © 2012 Wiley Periodicals, Inc.