Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases.
Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases.
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靶向 NLRP3 炎性体治疗中枢神经系统疾病
DOI：
10.3389/fnmol.2018.00320
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发表时间：
2018
影响因子：
4.8
通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Shao BZ;Cao Q;Liu C
中枢神经系统（CNS）是全世界人类健康的最大杀手之一。免疫和炎症反应的过度激活被认为是导致CNS疾病发病和进展的重要因素。在众多的免疫和炎症反应中，炎性小体作为一种蛋白质复合体越来越受到人们的关注。炎性小体的启动和激活与多种疾病的发生有关。NLRP 3炎性小体是炎性小体中研究最多的成员，与多种中枢神经系统疾病密切相关。本文就NLRP 3炎性小体在脑血管疾病、神经退行性疾病、多发性硬化、抑郁症等中枢神经系统疾病的发病机制和进展中的作用进行综述。此外，针对NLRP3炎性小体的治疗策略，用于治疗中枢神经系统疾病的几个将在此审查。
Central nervous system (CNS) is one of the largest killers of people’s health all over the world. The overactivation of the immune and inflammatory responses is considered as an important factor, contributing to the pathogenesis and progression of CNS disorders. Among all kinds of immune and inflammatory reaction, the inflammasome, a complex of proteins, has been drawn increasingly attention to by researchers. The initiation and activation of the inflammasome is involved in the onset of various kinds of diseases. The NLRP3 inflammasome, the most studied member of the inflammasome, is closely associated with many kinds of CNS disorders. Here in this review, the roles of the NLRP3 inflammasome in the pathogenesis and progression of several well-known CNS diseases would be discussed, including cerebrovascular diseases, neurodegenerative diseases, multiple sclerosis, depression as well as other CNS disorders. In addition, several therapeutic strategies targeting on the NLRP3 inflammasome for the treatment of CNS disorders would be described in this review.
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影响因子：
9.3
作者：
Benedek G;Chaudhary P;Meza-Romero R;Calkins E;Kent G;Offner H;Bourdette D;Vandenbark AA
通讯作者：
Vandenbark AA
HLA-DRα1-MMOG-35-55治疗实验性自身免疫性脑脊髓炎可减少中枢神经系统炎症，增强M2巨噬细胞频率并促进神经保护作用。
影响因子：
9.3
作者：
Benedek G;Meza-Romero R;Jordan K;Keenlyside L;Offner H;Vandenbark AA
通讯作者：
Vandenbark AA
影响因子：
6.1
作者：
Chen，Alex Yen-Yu;Tully，Tim
通讯作者：
Tully，Tim
影响因子：
8.7
作者：
Duncan JA;Canna SW
通讯作者：
Canna SW
影响因子：
9.3
作者：
Feng L;Chen Y;Ding R;Fu Z;Yang S;Deng X;Zeng J
通讯作者：
Zeng J