Hypothalamic paraventricular nucleus modulates maternal aggression in rats: Effects of ibotenic acid lesion and oxytocin antisense
Hypothalamic paraventricular nucleus modulates maternal aggression in rats: Effects of ibotenic acid lesion and oxytocin antisense
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DOI：
10.1016/s0031-9384(97)00434-4
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发表时间：
1998-02-01
影响因子：
2.9
通讯作者：
Lucion, AB
中科院分区：
文献类型：
--
作者：
Giovenardi, M;Padoin, MJ;Lucion, AB
中枢催产素(OT)似乎对母亲的行为至关重要。OT：通过下丘脑室旁核(PVN)的小细胞神经元，通过作用于PVN非垂体投射中的OT受体，发挥其生理和行为效应。本研究旨在分析产后第5天(高攻击期)和产后第18天(低攻击期)PVN和OT对母亲攻击行为的影响。在第一个实验中，向下丘脑室旁核内注入鹅膏藤酸，以损伤小细胞神经元。第二个实验旨在利用反义技术更具体地研究OT的影响。在产后第5天，鹅膏藤酸损毁PVN和反义注射可能使该核团的OT合成急剧减少都增加了母亲的攻击行为，而在产后第18天则没有记录到任何影响。我们可以得出结论，只有在哺乳期女性表现出高水平的攻击行为时，PVN的中枢投射才会在分娩后的一段受限时间内调节母亲的攻击性。(C)1998年爱思唯尔科学公司。
Central oxytocin (OT) appears to be crucial for maternal behavior. OT: through the parvocellular neurons of the hypothalamic paraventricular nucleus (PVN), can exert its physiological and behavioral effects by acting on OT receptors in nonpituitary projections of the PVN. The purpose of the present study was to analyze the role of the PVN and OT on maternal aggressive behavior in two different periods after delivery: on the fifth day (period of high aggressiveness) and on the eighteenth day postpartum (period of low aggressiveness). In the first experiment, ibotenic acid was injected into the PVN in order to lesion the parvocellular neurons. A second experiment was designed to study more specifically the effects of OT using the antisense technique. On the fifth day postpartum, both the PVN lesion by the ibotenic acid and a possible acute reduction of OT synthesis by the antisense administration in that nucleus increased maternal aggressive behavior, while on the eighteenth day postpartum no effect was recorded. We may conclude that central projections of the PVN modulate maternal aggression during a restricted period after delivery, only when lactating females show naturally high levels of aggressive behaviors. (C) 1998 Elsevier Science Inc.