VirusSeq: software to identify viruses and their integration sites using next-generation sequencing of human cancer tissue
VirusSeq: software to identify viruses and their integration sites using next-generation sequencing of human cancer tissue
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DOI：
10.1093/bioinformatics/bts665
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发表时间：
2013-01-15
期刊：
影响因子：
5.8
通讯作者：
Su, Xiaoping
中科院分区：
文献类型：
--
作者：
Chen, Yunxin;Yao, Hui;Su, Xiaoping
我们开发了一种新的算法方法，VirusSeq，用于使用下一代测序数据检测已知病毒及其在人类基因组中的整合位点。我们对来自癌症基因组图谱的256个人类癌症样本的全转录组测序（RNA-Seq）数据进行了评估。利用这些数据，我们证明了VirusSeq能够以高灵敏度和特异性准确地检测已知病毒及其整合位点。VirusSeq还可以使用人体组织的全基因组测序数据来执行此功能。
We developed a new algorithmic method, VirusSeq, for detecting known viruses and their integration sites in the human genome using next-generation sequencing data. We evaluated VirusSeq on whole-transcriptome sequencing (RNA-Seq) data of 256 human cancer samples from The Cancer Genome Atlas. Using these data, we showed that VirusSeq accurately detects the known viruses and their integration sites with high sensitivity and specificity. VirusSeq can also perform this function using whole-genome sequencing data of human tissue.