Status of LEPR Gene in PCB-exposed Population: A Quick Look.
Status of LEPR Gene in PCB-exposed Population: A Quick Look.
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PCB 暴露人群中 LEPR 基因的状况：快速浏览。
DOI：
10.1080/09723757.2013.11886193
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发表时间：
2013
影响因子：
0.1
通讯作者：
Dutta,SisirK
中科院分区：
文献类型：
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作者：
Ghosh,Somiranjan;Trnovec,Tomas;Palkovicova,Lubica;Hoffman,EricP;Washington,Kareem;Dutta,SisirK
早些时候，我们已经报道了多氯联苯（PCBs）暴露在斯洛伐克人口中的差异基因表达，与研究人群中某些疾病和疾病发展的可能性有关。在这里，我们报告说，下调LEPR（瘦素受体）基因在45个月的儿童可能已经在以后的生活中发展肥胖的后果。在一个小群体中进行的高通量qRT-PCR [Taqman低密度阵列（TLDA）]试验研究也证实了基因表达结果及其导致疾病后果的途径，并进行了进一步详细的大规模群体验证。该研究表明，使用选定的基因组分类器预测化学品暴露的长期影响的机会可能反映了环境毒物的暴露影响和风险。
Earlier, we have reported that Polychlorinated Biphenyls (PCBs) exposure in Slovak population has made differential gene expression that has linked to the possibilities of some diseases and disorder development in the studied population. Here we report that down-regulation of LEPR (Leptin receptor) gene in the 45-month children may have been following consequences in developing obesity later in life. A pilot high-throughput qRT-PCR [Taqman Low Density Array (TLDA)] study in a small population also corroborated the gene-expression results, and their pathways underlying the consequences of the diseases, amid further detailed large-scale population validation. The study shows the opportunity of predicting long-term effects of chemical exposures using selected genomic classifiers may reflect exposure effect and risk from environmental toxicants.