WT1 immunoreactivity in uterine papillary serous carcinomas is different from ovarian serous carcinomas.
WT1 immunoreactivity in uterine papillary serous carcinomas is different from ovarian serous carcinomas.
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子宫乳头状浆液性癌中的 WT1 免疫反应性与卵巢浆液性癌不同。
DOI：
10.1309/k84k-005f-tcb8-fv4b
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发表时间：
2002
影响因子：
3.5
通讯作者：
A. Uzieblo
中科院分区：
文献类型：
--
作者：
N. Goldstein;A. Uzieblo
WT 1弥漫性染色大多数卵巢浆液性癌;子宫乳头状浆液性癌的反应性尚未评估。我们研究了WT 1在13例国际妇产科联盟第1期和5例第3期或第4期子宫乳头状浆液性癌中的表达，并将其与30例卵巢浆液性癌的WT 1染色反应性进行了比较。用C19和6 F-H2抗体克隆评价WT 1反应性。所有18例子宫乳头状浆液性癌WT 1均无反应。非卵巢转移的5个高阶段子宫乳头状浆液性癌也是无反应的WT 1。相反，30例卵巢浆液性癌中有29例（97%）对WT 1呈反应性。WT 1反应在一个未知的原发性浆液性癌将建议它是从一个非子宫网站。这些发现背后的机制尚不清楚。它们提出了两种形态相似的肿瘤之间存在遗传差异的可能性。
WT1 diffusely stains most ovarian serous carcinomas; reactivity of uterine papillary serous carcinomas has not been evaluated. We studied WT1 expression in 13 International Federation of Gynecology and Obstetrics stage 1 and 5 stage 3 or 4 uterine papillary serous carcinomas without ovarian metastases and compared their reactivity with the WT1 staining of 30 ovarian serous carcinomas. WT1 reactivity was evaluated with the C19 and 6F-H2 antibody clones. All 18 uterine papillary serous carcinomas were nonreactive for WT1. The nonovarian metastases of the 5 high-stage uterine papillary serous carcinomas also were nonreactive for WT1. In contrast, 29 (97%) of 30 ovarian serous carcinomas were reactive for WT1. WT1 reactivity in an unknown primary serous carcinoma would suggest it is from a nonuterine site. The mechanisms underlying these findings are unknown. They raise the possibility of genetic differences between the 2 morphologically similar neoplasms.
影响因子：
10.5
作者：
PELLETIER, J;SCHALLING, M;HOUSMAN, D
通讯作者：
HOUSMAN, D
DOI：
10.1073/pnas.88.21.9618
发表时间：
1991-11-01
影响因子：
11.1
作者：
HABER, DA;SOHN, RL;HOUSMAN, DE
通讯作者：
HOUSMAN, DE
腹膜乳头状浆液性癌中 WT1 基因的遗传改变。
DOI：
10.1006/gyno.1999.5711
发表时间：
2000
期刊：
Gynecologic oncology.
影响因子：
--
作者：
Schorge,JO;Miller,YB;Qi,LJ;Muto,MG;Welch,WR;Berkowitz,RS;Mok,SC
通讯作者：
Mok,SC