Inflammatory cytokines and non-alcoholic fatty liver disease (NAFLD) in obese children and adolescents
Inflammatory cytokines and non-alcoholic fatty liver disease (NAFLD) in obese children and adolescents
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DOI：
10.20960/nh.1317
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发表时间：
2018-02-01
期刊：
影响因子：
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通讯作者：
Rodrigues-Silva, Luciana
中科院分区：
文献类型：
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作者：
Ferraz-de-Assunção, Silvana-Neves;Amaral-Boa-Sorte, Ney-Christian;Rodrigues-Silva, Luciana
引言：非酒精性脂肪肝的特征是脂肪在肝内沉积。它是世界上最普遍的肝脏疾病，影响肥胖儿童和青少年。其病理生理学尚未完全了解，尽管它通常与胰岛素抵抗有关。这反过来又是由于肥胖症常见的炎症状况。因此，本研究的目的是描述促炎细胞因子在肥胖儿童和青少年中的行为，有和没有非酒精性脂肪肝疾病。方法：从年龄在8-18岁的连续90名肥胖个体中获得空腹静脉血样，用于实验室测定高血糖、基础胰岛素和稳态模型评估胰岛素抵抗指数，以及炎症标志物肿瘤坏死因子-α（1 NF-α）、白细胞介素2和6（IL-2和IL-6）、干扰素-γ和高敏C-反应蛋白。临床评价包括体重、身高和腰围。我们使用体重指数/年龄指标评估超重的严重程度。通过超声检查确定脂肪变性程度。定量和定性变量分别表示为集中趋势/分散和简单/相对频率的措施，使用社会科学统计程序，版本20.0。结果：共研究了90名个体，平均年龄为11.98（2.72）岁，其中48名（53%）为男性。根据年龄（BMI/i）和性别（z评分）的体重指数（BMI）将38名（42.2%）参与者分类为肥胖，52名（57.7%）参与者分类为重度肥胖;在56名（62.2%）参与者中确定了肝脏脂肪变性，其中约90%呈现I级脂肪变性。炎症标志物TNF-α和C-反应蛋白的增加，在研究的样品和相关性在一个积极的和统计学上显着的方式与体重/年龄和sex.Conclusion指数：肝脂肪变性是普遍存在的儿童和青少年研究组，但不相关的肥胖程度。
Introduction: Non-alcoholic fatty liver disease is characterized by the intrahepatic deposition of fat. It is the most prevalent liver disease in the world, affecting obese children and adolescents. Its pathophysiology is not fully understood, although it is often related to insulin resistance. This in turn would be due to an inflammatory condition common to obesity. Thus, the objective of this study was to describe the behavior of proinflammatory cytokines in obese children and adolescents, with and without non-alcoholic fatty liver disease.Method: A fasting venous blood sample was obtained of consecutive 90 obese individuals aged 8-18 years, of both sexes, for laboratory determinations of glycaemia, basal insulin and homeostasis model assessment insulin-resistance index, and the inflammatory markers tumor necrosis factor-alpha (1NF-alpha), interleukins 2 and 6 (IL-2 and IL-6), interferon-gamma and high sensitive C-reactive protein. The clinical evaluation included weight, height and waist circumference. We used the body mass index/age indicator for the severity of overweight assessment. The degrees of steatosis were determined by ultrasonography. Quantitative and qualitative variables were respectively expressed by measures of central tendency/dispersion and simple/relative frequency, using Statistical Program for Social Sciences, version 20.0. A p-value < 0.05 was considered as significant.Results: A total of 90 individuals were studied, with a mean age of 11.98 (2.72) years, of which 48 (53%) were male. The body mass index (BMI) for age (BMI/i) and sex (z-score) classified 38 (42.2%) participants as obese and 52 (57.7%) as severe obese; Hepatic steatosis was identified in 56 (62.2%) participants and approximately 90% of them presented grade I steatosis. The inflammatory markers TNF-alpha, and C-reactive protein were increased in the studied sample and correlated in a positive and statistically significant way with the index of body mass/age and sex.Conclusion: Hepatic steatosis was prevalent in the group of children and adolescents studied, but was not related to obesity degrees.