Hypertension is the most common component of metabolic syndrome and the greatest contributor to carotid arteriosclerosis in apparently healthy Japanese individuals
Hypertension is the most common component of metabolic syndrome and the greatest contributor to carotid arteriosclerosis in apparently healthy Japanese individuals
复制标题
DOI：
10.1291/hypres.28.27
复制
发表时间：
2005-01-01
影响因子：
5.4
通讯作者：
Yamakado, M
中科院分区：
文献类型：
--
作者：
Ishizaka, N;Ishizaka, Y;Yamakado, M
被称为代谢综合征的一系列代谢和血流动力学风险因素被认为是缺血性心血管疾病和中风的风险因素。通过分析8,144名19-88岁健康体检人群的横断面数据，我们调查了代谢综合征的患病率，根据修改后的国家胆固醇教育计划(NCEP)标准，对应于以下五个类别：甘油三酯=150 mg/dl；高密度脂蛋白(HDL)-胆固醇；40 mg/dl；女性：50 mg/dl；空腹血糖=110 mg/dl；收缩/舒张压&Gt；=130/85 mm Hg；和体重指数&Gt；25 kg/m(2)。我们发现，代谢综合征的患病率男性为19%，女性为7%。对年龄进行调整后，发现代谢综合征在男性中显著高于女性，优势比为3.08(95%可信区间为2.62-3.61，p<；0.0001)。在代谢/血流动力学的五个危险因素中，高血压在患有代谢综合征的个体中最常见，男性为85%，女性为87%。此外，对年龄、性别、血清总胆固醇水平和吸烟状况进行多因素Logistic回归分析显示，在代谢/血流动力学危险因素中，高血压对颈动脉斑块的优势比最大(1.43，95%CI 1.27~1.60)。这些数据强调了控制血压对于降低看似健康的个体中代谢综合征和颈动脉硬化的风险的重要性。
The cluster of metabolic and hemodynamic risk factors known as metabolic syndrome is known to be a risk factor for ischemic cardiovascular diseases and stroke. By analyzing the cross-sectional data from 8,144 individuals (age 19-88 years) who underwent general health screening, we have investigated the prevalence of metabolic syndrome, as diagnosed by modified-National Cholesterol Education Program (NCEP) criteria corresponding to the following five categories: triglycerides >= 150 mg/dl; high density lipoprotein (HDL)-cholesterol < 40 mg/dl in men or < 50 mg/dl in women; fasting plasma glucose >= 110 mg/dl; systolic/diastolic blood pressure >= 130/85 mmHg; and body mass index > 25 kg/m(2). We found that the prevalence of metabolic syndrome was 19% in men and 7% in women. After adjustment for age, metabolic syndrome was found to be significantly more prevalent in men than in women, with an odds ratio of 3.08 (95% confidence interval [CI] 2.62-3.61, p < 0.0001). Among the five metabolic/hemodynamic risk factor components, hypertension was observed most frequently in individuals with metabolic syndrome, at 85% in men and 87% in women. In addition, multivariate logistic regression analysis adjusted for age, sex, serum total cholesterol levels, and smoking status showed that hypertension possessed the greatest odds ratio (1.43, 95% CI 1.27-1.60) for carotid plaque among the metabolic/hemodynamic risk factors. These data emphasize the importance of controlling blood pressure for reducing the risk of both metabolic syndrome and carotid arteriosclerosis in apparently healthy individuals.