CRYPTOCOCCAL ENDOPHTHALMITIS - CASE-REPORT AND REVIEW
CRYPTOCOCCAL ENDOPHTHALMITIS - CASE-REPORT AND REVIEW
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DOI：
10.1093/clinids/14.5.1069
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发表时间：
1992-05-01
影响因子：
11.8
通讯作者：
KAUFFMAN, CA
中科院分区：
文献类型：
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作者：
CRUMP, JRC;ELNER, SG;KAUFFMAN, CA
新型隐球菌是一种机会性真菌，易感染脑膜。中枢神经系统隐球菌感染的眼部后遗症通常包括颅神经麻痹或继发于颅内压增高的视神经乳头水肿。眼内隐球菌病发生频率较低，在过去的23年中，只有27例报告，包括这里提出的情况。眼内感染以脉络膜视网膜病变和玻璃体炎最常见。在27名患者中，仅11名（41%）发现了基础疾病。值得注意的是，22例CNS受累患者中有6例（27%）眼部病变先于症状性脑膜炎。对于7例患者，诊断是由组织学检查标本的水或玻璃体液;另外8例患者，诊断后眼球摘除术或尸检。眼部受累常导致严重的视力丧失;视力恢复正常是不寻常的。早期识别和治疗可能会改善这些患者的预后。
Cryptococcus neoformans is an opportunistic fungus with a predilection for infecting the meninges. Ocular sequelae of cryptococcal infections of the CNS usually include cranial nerve palsies or papilledema secondary to increased intracranial pressure. Intraocular cryptococcosis occurs less frequently, and over the last 23 years, only 27 cases have been reported, including the case presented here. Intraocular infection was most often manifested by chorioretinal lesions and vitritis. Underlying diseases were detected in only 11 (41%) of the 27 patients. Of note, ocular lesions preceded symptomatic meningitis in six (27%) of 22 patients with CNS involvement. For seven patients, the diagnosis was made by histologic examination of specimens of aqueous or vitreous humor; for another eight patients, the diagnosis was made after enucleation or at autopsy. Ocular involvement frequently led to severe visual loss; return of vision to normal was unusual. Early recognition and treatment may improve outcome for these patients.